Short R D, Robinson E C, Lington A W, Chin A E
Toxicol Ind Health. 1987 Jun;3(2):185-95. doi: 10.1177/074823378700300213.
Male Fischer 344 rats and cynomolgus monkeys were treated with various doses of di(2-ethylhexyl)phthalate (DEHP) for at least 21 days. There was metabolic, biochemical, and morphological evidence for peroxisomal proliferation in rats that consumed diets containing 1000 ppm DEHP and above. These diets were estimated to provide average daily doses of about 100 mg/kg of DEHP. In contrast, peroxisomal proliferation was not observed in monkeys that received up to 500 mg/kg/day of DEHP by gavage. The results of this study suggest that rats do not provide a good model for predicting the results of DEHP exposure on peroxisomal proliferation in higher primates.
雄性Fischer 344大鼠和食蟹猴接受了不同剂量的邻苯二甲酸二（2-乙基己基）酯（DEHP）处理，持续至少21天。在食用含1000 ppm及以上DEHP饲料的大鼠中，有代谢、生化和形态学证据表明存在过氧化物酶体增殖。据估计，这些饲料提供的DEHP平均日剂量约为100 mg/kg。相比之下，通过灌胃给予高达500 mg/kg/天DEHP的猴子未观察到过氧化物酶体增殖。本研究结果表明，大鼠并非预测DEHP暴露对高等灵长类动物过氧化物酶体增殖影响结果的良好模型。
