丁硫氨酸亚砜亚胺和半胱氨酸对大鼠丁基羟基甲苯肝毒性的影响。

Effects of buthionine sulfoximine and cysteine on the hepatotoxicity of butylated hydroxytoluene in rats.

作者信息

Nakagawa Y

出版信息

Toxicol Lett. 1987 Aug;37(3):251-6. doi: 10.1016/0378-4274(87)90139-1.

Abstract

Pretreatment with buthionine sulfoximine (BSO; 900 mg/kg) induced the elevation of serum GOT and GPT activities in a non-toxic dose of butylated hydroxytoluene (BHT; 250-500 mg/kg) in rats. The elevation of serum enzyme activities was accompanied by a remarked depletion of the hepatic glutathione (GSH) concentration. In contrast, pretreatment with cysteine (100-200 mg/kg) inhibited the elevation of serum enzyme activities at a toxic dose of BHT (1000 mg/kg). The effects of BSO and cysteine on BHT-induced hepatotoxicity in rats are discussed.

摘要

用丁硫氨酸亚砜亚胺（BSO；900毫克/千克）预处理可诱导无毒剂量的丁基化羟基甲苯（BHT；250 - 500毫克/千克）使大鼠血清谷草转氨酶（GOT）和谷丙转氨酶（GPT）活性升高。血清酶活性的升高伴随着肝脏谷胱甘肽（GSH）浓度的显著降低。相比之下，用半胱氨酸（100 - 200毫克/千克）预处理可抑制毒性剂量的BHT（1000毫克/千克）所致的血清酶活性升高。本文讨论了BSO和半胱氨酸对BHT诱导的大鼠肝毒性的影响。