Myre S A, McCann J, First M R, Cluxton R J
Ther Drug Monit. 1987 Jun;9(2):161-5. doi: 10.1097/00007691-198706000-00006.
The effect of trimethoprim (TMP) on serum creatinine concentration (SCr) was studied in 10 healthy (H) subjects and nine subjects with chronic renal failure (CRF). Each volunteer was given TMP 100 mg perorally every 12 h for 10 days followed by a 7-day washout period. SCr was measured colorimetrically immediately before the study (baseline), on day 10 of TMP, and 7 days after TMP had been discontinued. SCr increased an average of 14.8% from baseline during TMP administration in the H volunteers, but this increase was not statistically significant. During TMP administration to the CRF volunteers, a pronounced elevation (34.6%) of mean SCr from baseline was observed (p less than 0.05). SCr returned to baseline values in both groups following the 7-day washout period. These results are consistent with the hypothesis that TMP competitively inhibits the renal tubular secretion of creatinine.
在10名健康受试者（H）和9名慢性肾衰竭（CRF）受试者中研究了甲氧苄啶（TMP）对血清肌酐浓度（SCr）的影响。每位志愿者每12小时口服100 mg TMP，持续10天，随后有7天的洗脱期。在研究前（基线）、TMP治疗的第10天以及停用TMP 7天后，用比色法测量SCr。在H组志愿者服用TMP期间，SCr较基线平均升高了14.8%，但这种升高无统计学意义。在给CRF志愿者服用TMP期间，观察到平均SCr较基线有显著升高（34.6%）（p<0.05）。7天洗脱期后，两组的SCr均恢复到基线值。这些结果与TMP竞争性抑制肾小管肌酐分泌的假说一致。
