Uvelius B, Nelson C E, Persson L, Rosengren E
Urol Int. 1987;42(2):105-7. doi: 10.1159/000281865.
Ornithine decarboxylase (ODC) activity and contents of putrescine, spermidine and spermine were determined in cortical and medullary tissue and clear cell tumours in human kidneys. Medullary ODC activity was 75 +/- 9% (n = 6; p less than 0.05) of the respective cortical value. The ODC activity in renal tumours varied considerably but did not differ significantly from the respective cortical values. Similar concentrations of putrescine were found in cortex and medulla, but a 5-fold increase was found in the tumours (p less than 0.02). Significantly lower values (p less than 0.01) of spermidine and spermine were found in medulla when compared to cortex. No significant change was found for these amines in the carcinomas when compared with corresponding cortical tissue.
测定了人肾皮质、髓质组织及透明细胞肿瘤中鸟氨酸脱羧酶（ODC）活性以及腐胺、亚精胺和精胺的含量。髓质ODC活性为相应皮质值的75±9%（n = 6；p＜0.05）。肾肿瘤中的ODC活性差异很大，但与相应的皮质值相比无显著差异。皮质和髓质中腐胺浓度相似，但肿瘤中腐胺浓度增加了5倍（p＜0.02）。与皮质相比，髓质中亚精胺和精胺的值显著较低（p＜0.01）。与相应的皮质组织相比，癌组织中这些胺类物质无显著变化。
