Womack J E, O'Donovan G A
J Bacteriol. 1978 Nov;136(2):825-7. doi: 10.1128/jb.136.2.825-827.1978.
During rapid growth, the excretion of pyrimidines, predominantly uracil, is a common phenomenon in procaryotes and eucaryotes. In Escherichia coli, some K-12 strains excrete orotic acid and not uracil. This is caused by a mutation in the pyrF gene.
在快速生长过程中,嘧啶(主要是尿嘧啶)的排泄是原核生物和真核生物中的常见现象。在大肠杆菌中,一些K-12菌株排泄乳清酸而非尿嘧啶。这是由pyrF基因突变引起的。