Synaptic Biology and Cognition Laboratory, The Florey Institute for Neuroscience and Mental Health, Parkville, Victoria, Australia; The Florey Department of Neuroscience and Mental Health, The University of Melbourne, Parkville, Victoria, Australia.
Centre for Mental Health, School of Health Sciences, Swinburne University, Melbourne, Victoria, Australia; Department of Psychiatry, St Vincent's Hospital, Melbourne, Victoria, Australia.
Psychiatry Res. 2022 Nov;317:114850. doi: 10.1016/j.psychres.2022.114850. Epub 2022 Sep 13.
Different regions of the cortex have been implicated in the pathophysiology of schizophrenia. Recently published data suggested there are many more changes in gene expression in the frontal pole (Brodmann's Area (BA) 10) compared to the dorsolateral prefrontal cortex (BA 9) and the anterior cingulate cortex (BA 33) from patients with schizophrenia. These data argued that the frontal pole is significantly affected by the pathophysiology of schizophrenia. The frontal pole is a region necessary for higher cognitive functions and is highly interconnected with many other brain regions. In this review we summarise the growing body of evidence to support the hypothesis that a dysfunctional frontal pole, due at least in part to its widespread effects on brain function, is making an important contribution to the pathophysiology of schizophrenia. We detail the many structural, cellular and molecular abnormalities in the frontal pole from people with schizophrenia and present findings that argue the symptoms of schizophrenia are closely linked to dysfunction in this critical brain region.
皮层的不同区域与精神分裂症的病理生理学有关。最近发表的数据表明，与精神分裂症患者的背外侧前额叶皮层（BA9）和前扣带回皮层（BA33）相比，额叶（Brodmann 区（BA）10）的基因表达变化更多。这些数据表明额叶受到精神分裂症病理生理学的显著影响。额叶是进行更高认知功能所必需的区域，与许多其他大脑区域高度相互连接。在这篇综述中，我们总结了越来越多的证据支持以下假设，即由于额叶对大脑功能的广泛影响而导致的功能障碍，对精神分裂症的病理生理学做出了重要贡献。我们详细介绍了精神分裂症患者额叶的许多结构、细胞和分子异常，并提出了精神分裂症的症状与该关键大脑区域的功能障碍密切相关的发现。
