[实验性肾和肝损伤大白鼠阿莫西林药代动力学的变化]
[Changes in amoxicillin pharmacokinetics in white rats with experimentally damaged kidneys and liver].
作者信息
Lashev L, Fink-Gremels J
出版信息
Vet Med Nauki. 1987;24(1):57-63.
PMID:3617467
Abstract
The blood level and the basic pharmacokinetic parameters (kel, Cop, T 1/2, AUC) of amoxicillin trihydrate were studied following its oral application to albino rats with experimentally injured kidneys (potassium chromate) and liver (tetrachloromethane). It was found that the impairment of these organs changed the extent of absorption, distribution, and excretion of the antibiotic.
摘要
在对白化病大鼠口服三水合阿莫西林后，研究了其血液水平以及基本药代动力学参数（消除速率常数、药峰浓度、半衰期、药时曲线下面积），这些大鼠的肾脏（用铬酸钾）和肝脏（用四氯化碳）受到实验性损伤。结果发现，这些器官的损伤改变了抗生素的吸收、分布和排泄程度。
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