甲氨蝶呤相关性淋巴组织增生异常表现为腭部肿块。
Unusual manifestation of methotrexate-associated lymphoproliferative disorder as a palatal mass.
机构信息
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
出版信息
BMJ Case Rep. 2022 Sep 29;15(9):e250616. doi: 10.1136/bcr-2022-250616.
Methotrexate-associated lymphoproliferative disorder (MTX-LPD) can occur in the oral cavity, and only a few cases with palatal involvement have been reported. Chemotherapy may be needed if there is no remission after the withdrawal of MTX. We report a case of MTX-LPD presenting with a swelling of the palate that required chemotherapy. A woman in her 70s with rheumatoid arthritis reported a swelling on the left side of the palate. Her condition was diagnosed as Epstein-Barr virus-negative diffuse large B-cell lymphoma (MTX-LPD). Since the mass did not remit after MTX withdrawal, she underwent five courses of chemotherapy. Currently, the patient is in complete remission. In patients on MTX who develop a swelling on the palate, MTX-LPD should be included among the differential diagnostic possibilities. Diagnosis and treatment of MTX-LPD call for consultation with a haematologist. If the mass fails to regress following withdrawal of MTX, appropriate chemotherapy is indicated.
甲氨蝶呤相关性淋巴组织增生性疾病（MTX-LPD）可发生于口腔，仅有少数腭部受累的病例报道。如果甲氨蝶呤停药后无缓解，可能需要化疗。我们报告了一例以腭肿胀为表现的 MTX-LPD 病例，该病例需要化疗。一名 70 多岁的女性类风湿关节炎患者诉左侧腭部肿胀。她的病情被诊断为 EBV 阴性弥漫性大 B 细胞淋巴瘤（MTX-LPD）。由于甲氨蝶呤停药后肿块未消退，她接受了五轮化疗。目前，患者完全缓解。在接受 MTX 治疗的患者中，如果出现腭部肿胀，应将 MTX-LPD 纳入鉴别诊断的可能。MTX-LPD 的诊断和治疗需要血液科医生的咨询。如果 MTX 停药后肿块没有消退，应给予适当的化疗。
Zotero 插件