Merigan W H, Eskin T A
Vision Res. 1986;26(11):1751-61. doi: 10.1016/0042-6989(86)90125-2.
Anatomical and physiological studies indicate major structural and functional differences between the two parallel retinogeniculate visual pathways in the macaque. We have examined the contribution of these pathways to achromatic visual capacities by behaviorally testing spatio-temporal vision in monkeys with severe damage to the P beta (medium cell) pathway. This loss was produced by systemic administration of a neurotoxicant, acrylamide monomer, a treatment that apparently spares other visual system neurons. Monkeys dosed with acrylamide showed large reductions of contrast sensitivity at high spatial as well as low temporal frequencies. On the other hand, they had normal sensitivity for stimuli of high temporal, low spatial frequency. In addition, dosed monkeys retained normal flicker resolution thresholds for unpatterned stimuli. These findings suggest that the medium cell retinogeniculate pathway contributes primarily to the detection of higher spatial, lower temporal frequencies, while the large cell pathway is involved primarily in sensitivity to lower spatial and higher temporal frequencies.
解剖学和生理学研究表明，猕猴的两条平行视网膜神经节视觉通路在结构和功能上存在重大差异。我们通过行为测试严重损伤Pβ（中型细胞）通路的猴子的时空视觉，研究了这些通路对无色视觉能力的贡献。这种损伤是通过全身给予神经毒剂丙烯酰胺单体造成的，这种处理显然不会损害其他视觉系统神经元。用丙烯酰胺给药的猴子在高空间频率和低时间频率下的对比敏感度大幅降低。另一方面，它们对高时间频率、低空间频率的刺激具有正常的敏感度。此外，给药的猴子对无图案刺激的闪烁分辨阈值保持正常。这些发现表明，中型细胞视网膜神经节通路主要有助于检测较高空间频率、较低时间频率，而大细胞通路主要参与对较低空间频率和较高时间频率的敏感度。
