Trapeznikov N N, Khasanov Sh R, Iavorskiĭ V V
Vopr Onkol. 1987;33(6):40-6.
Out of 2018 patients, skin melanoma occurred in IO2 (5%) cases during pregnancy. Three-, five- and ten year survival was analysed in the latter cases versus term of pregnancy, abortion and the stage of the disease. Also comparison was made between the said group, another 42 females who developed tumors during lactation period and 599 normally-cycling females of reproductive age who were not pregnant when melanoma appeared (controls). Significantly lower 10-year survival was observed in pregnant patients, as compared with those who were not pregnant (p less than 0.05). Five- and ten-year survivals were significantly lower in cases of stage I tumor during the latter half of pregnancy than in skin melanoma patients who were not pregnant (p less than 0.05). Abortion during the first half of pregnancy was found to produce an adverse effect on prognosis in stage I tumor patients while this effect was reversed in stage II tumor. No significant differences were found between 3-, 5- and 10-year survival in melanoma patients who had pregnancies before the disease and those who had not (p greater than 0.05).
在2018例患者中，102例（5%）在孕期发生皮肤黑色素瘤。对这些患者的3年、5年和10年生存率与孕期、流产及疾病分期进行了分析。同时，将该组患者与另外42例在哺乳期发生肿瘤的女性以及599例黑色素瘤出现时未怀孕的正常月经周期育龄女性（对照组）进行了比较。与未怀孕患者相比，怀孕患者的10年生存率显著降低（p<0.05）。妊娠后半期I期肿瘤患者的5年和10年生存率显著低于未怀孕的皮肤黑色素瘤患者（p<0.05）。发现妊娠前半期流产对I期肿瘤患者的预后产生不利影响，而在II期肿瘤中这种影响则相反。疾病发生前怀孕的黑色素瘤患者与未怀孕的患者在3年、5年和10年生存率方面未发现显著差异（p>0.05）。
