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[线粒体和脂质体膜中与氧化反应偶联的离子转运的诱导]

[Induction of ion transport coupled to oxidative reactions in the membranes of mitochondria and liposomes].

作者信息

Kostava V T, Sharyshev A A, Rakhmaninova A B, Votiakova T V, Evtodienko Iu V

出版信息

Biofizika. 1979 Mar-Apr;24(2):230-4.

PMID:36176
Abstract

The mechanism of induction of potassium permeability for mitochondrial membranes under special conditions was under study. Conditions were such as: 1--incubation of mitochondria in medium with low meaning of pH (6,0--6,5), 2--incubation in preseace of electrophylic agent--p-(N,N-di-2-chloroethyl) aminophenylacetic acid, which is hydrolized to HCl and 3-lipidsoluble acid, 2,4-dinitrophenol. It is shown that the named mechanism in any case requires the oxidation of lipids of mitochondrial membranes.

摘要

正在研究特殊条件下线粒体膜钾通透性诱导机制。这些条件如下:1——线粒体在pH值较低(6.0 - 6.5)的培养基中孵育;2——在亲电试剂——对(N,N - 二 - 2 - 氯乙基)氨基苯乙酸存在下孵育,该试剂水解生成HCl和3 - 脂溶性酸2,4 - 二硝基苯酚。结果表明,无论在何种情况下,上述机制都需要线粒体膜脂质的氧化。

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