Bjonholm E, Soderholm S, Stephansson O, Askling H H
Department of Infectious Diseases, Mälarsjukhuset, Eskilstuna, Sweden.
Public Health Agency, Sweden.
New Microbes New Infect. 2022 Aug 29;48:101017. doi: 10.1016/j.nmni.2022.101017. eCollection 2022 Jul.
Tick-borne encephalitis (TBE) incidence has been increasing in Europe the last decades, but very few cases in pregnant women have been described. We present two cases and describe the serology of both mother and infant at the time of diagnosis and delivery, as well as at months 3, 6, 9, and 12 of follow-up. In both cases, pregnancies and infants developed normally. The mothers had moderate-to severe symptoms of TBE and were positive for IgM and IgG at the time of diagnosis, and throughout the follow up period whilst both infants were PCR- and IgM-negative and positive for IgG during their first months in life. Declining IgG titres were seen in the infants during follow-up until they became negative at the age of nine months. TBE IgG was vertically transmitted in these two cases of infants born to TBE-infected mothers.
在过去几十年中，欧洲蜱传脑炎（TBE）的发病率一直在上升，但孕妇感染该疾病的病例却鲜有报道。我们报告了两例病例，并描述了母亲和婴儿在诊断和分娩时以及随访的第3、6、9和12个月时的血清学情况。在这两例病例中，妊娠过程和婴儿发育均正常。母亲们出现了中度至重度的TBE症状，诊断时IgM和IgG呈阳性，并且在整个随访期间一直保持阳性，而两名婴儿在出生后的头几个月PCR检测和IgM均为阴性，IgG为阳性。随访期间，婴儿体内的IgG滴度逐渐下降，直到9个月大时转为阴性。在这两例由感染TBE的母亲所生的婴儿中，TBE IgG是通过垂直传播的。
