Department of Pathology, Harvard Medical School, Massachusetts General Hospital, Boston, Massachusetts, USA.
Division of Pathology, Center for Genetic Medicine Research, Children's National Health System, Washington, District of Columbia, USA.
Thyroid. 2022 Nov;32(11):1423-1428. doi: 10.1089/thy.2022.0060.
Thyroblastoma, a primary thyroid neoplasm with histological features of primitive thyroid tissue has recently been described and is included as a distinct entity in the most recent edition of the World Health Organization (WHO) Classification of Tumors (5th edition). In this study, we expand the clinical, morphological, and molecular profile of this aggressive neoplasm. The patients are females, 19 and 45 years of age, referred for large thyroid nodules. Tumor morphology is biphasic, composed of nests and follicles of epithelial cells, some with colloid-like secretions reminiscent of fetal thyroid follicles intertwined with a primitive stromal spindle cell component. By immunohistochemistry, the epithelial component is diffusely positive for PAX8 and TTF1 markers. Molecular studies showed aberrations. A primary primitive thyroid malignancy reminiscent of early fetal embryology with no teratoid element, recently reported as thyroblastoma represents a unique entity, novel in its description, and is likely underdiagnosed.
甲状腺胚细胞瘤，一种具有原始甲状腺组织组织学特征的原发性甲状腺肿瘤，最近被描述，并被纳入世界卫生组织（WHO）肿瘤分类（第五版）的最新版本中。在这项研究中，我们扩展了这种侵袭性肿瘤的临床、形态和分子特征。患者为女性，年龄分别为 19 岁和 45 岁，因甲状腺结节就诊。肿瘤形态呈双相性，由上皮细胞的巢和滤泡组成，一些具有类似于胎儿甲状腺滤泡的胶体样分泌物，与原始间质梭形细胞成分交织在一起。通过免疫组织化学，上皮成分弥漫性表达 PAX8 和 TTF1 标志物。分子研究显示存在异常。最近报道的一种无畸胎样成分、类似于早期胎儿胚胎学的原发性原始甲状腺恶性肿瘤，被称为甲状腺胚细胞瘤，代表一种独特的实体，在描述上是新颖的，可能被低估。
