Department of Pharmacology, Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul, 06591, Korea.
Department of Physiology, University of Toronto, Toronto, ON, Canada.
Arch Pharm Res. 2022 Oct;45(10):671-692. doi: 10.1007/s12272-022-01408-z. Epub 2022 Sep 30.
The Golgi apparatus is an essential cellular organelle that mediates homeostatic functions, including vesicle trafficking and the post-translational modification of macromolecules. Its unique stacked structure and dynamic functions are tightly regulated, and several Golgi proteins play key roles in the functioning of unconventional protein secretory pathways triggered by cellular stress responses. Recently, an increasing number of studies have implicated defects in Golgi functioning in human diseases such as cancer, neurodegenerative, and immunological disorders. Understanding the extraordinary characteristics of Golgi proteins is important for elucidating its associated intracellular signaling mechanisms and has important ramifications for human health. Therefore, analyzing the mechanisms by which the Golgi participates in disease pathogenesis may be useful for developing novel therapeutic strategies. This review articulates the structural features and abnormalities of the Golgi apparatus reported in various diseases and the suspected mechanisms underlying the Golgi-associated pathologies. Furthermore, we review the potential therapeutic strategies based on Golgi function.
高尔基复合体是一种重要的细胞细胞器，介导着包括囊泡运输和大分子的翻译后修饰在内的内稳态功能。其独特的堆叠结构和动态功能受到严格调控，几种高尔基蛋白在细胞应激反应引发的非常规蛋白分泌途径的功能中发挥着关键作用。最近，越来越多的研究表明，高尔基复合体功能缺陷与人类疾病有关，如癌症、神经退行性疾病和免疫性疾病。了解高尔基蛋白的非凡特性对于阐明其相关的细胞内信号机制非常重要，对人类健康也有重要的影响。因此，分析高尔基参与疾病发病机制的机制可能有助于开发新的治疗策略。本文阐述了在各种疾病中报道的高尔基器的结构特征和异常，以及与高尔基相关病变相关的疑似机制。此外，我们还综述了基于高尔基功能的潜在治疗策略。
