Sterry W
Z Hautkr. 1987 May 1;62(9):697-704.
Colchicine is one of the oldest drugs known to us. During the last few years, it has been increasingly applied in the treatment of systemic dermatoses. Particularly in dermatoses mediated by neutrophils, colchicine has settled among other therapies. With regard to Behçet's disease, it has even become the treatment of choice. The present review deals with further dermatological disorders sensitive to colchicine; in addition, we mention those dermatoses which do not show any therapeutic response to colchicine. The treatment with colchicine requires profound knowledge of the pharmacokinetics and mode of action regarding this substance, as well as the possible side effects. This knowledge allows safe and responsible treatment with colchicine. It has to be considered, however, that in the Federal Republic of Germany colchicine has not been registered for dermatological indications yet.
秋水仙碱是我们已知的最古老的药物之一。在过去几年中，它越来越多地应用于系统性皮肤病的治疗。特别是在由中性粒细胞介导的皮肤病中，秋水仙碱已成为其他治疗方法之一。关于白塞病，它甚至已成为首选治疗方法。本综述涉及对秋水仙碱敏感的其他皮肤病；此外，我们还提及那些对秋水仙碱无治疗反应的皮肤病。使用秋水仙碱进行治疗需要对该物质的药代动力学、作用方式以及可能的副作用有深入了解。这些知识有助于安全、合理地使用秋水仙碱进行治疗。然而，必须考虑到在德意志联邦共和国，秋水仙碱尚未获批用于皮肤病适应症。
