Shim C, Stover D E, Williams M H
J Allergy Clin Immunol. 1978 Dec;62(6):363-7. doi: 10.1016/0091-6749(78)90137-9.
Corticosteroid drugs are often employed in the treatment of patients with chronic bronchitis. Although some patients respond favorably to such therapy, the characteristics of such patients are not known. Twenty-four patients with chronic bronchitis were treated with prednisone 30 mg daily or placebo for one week each in a double-blind crossover study. The following were monitored before and after each treatment period: physical examination, symptoms, peripheral blood eosinophil count, sputum cell exmination, forced vital capacity (FVC), before and after isoproterenol aerosol. Seven of 24 patients had an FEV1 increase greater than 30% of the control value on prednisone but not on placebo. Blood eosinophil count was elevated (greater than or equal to 350/mm(3)) in 7 patients; 2 of these 7 improved on steroid. Sputum cell examination revealed preponderance of eosinophils in 1, and occasional clumps of eosinophils in 8. Seven of these 9 responded to steroid. Sputum but not blood eosinophilia is a good predictor of a favorable response to steroid therapy.
皮质类固醇药物常用于治疗慢性支气管炎患者。虽然有些患者对这种治疗反应良好，但这类患者的特征尚不清楚。在一项双盲交叉研究中，24例慢性支气管炎患者分别接受每日30毫克泼尼松或安慰剂治疗，各为期一周。在每个治疗期前后监测以下指标：体格检查、症状、外周血嗜酸性粒细胞计数、痰液细胞检查、异丙肾上腺素气雾剂吸入前后的用力肺活量（FVC）。24例患者中有7例在服用泼尼松时第一秒用力呼气量（FEV1）较对照值增加超过30%，而服用安慰剂时则未增加。7例患者血液嗜酸性粒细胞计数升高（大于或等于350/mm³）；这7例中有2例在使用类固醇治疗后病情改善。痰液细胞检查显示，1例患者嗜酸性粒细胞占优势，8例患者有偶尔的嗜酸性粒细胞团块。这9例中有7例对类固醇治疗有反应。痰液而非血液嗜酸性粒细胞增多是对类固醇治疗有良好反应的一个良好预测指标。
