Chupin L, Herrmann J M, Maillet R, Gillet J Y, Colette C, Gibey R, Bechtel P, Henry J C
J Gynecol Obstet Biol Reprod (Paris). 1978 May-Jun;7(4):849-54.
The use of heparin to interfere with the appearance of fetal maldevelopment (or to correct it) is logical but the results are difficult to prove because it is difficult to be certain of early diagnosis at the time when therapy has the best chances of being efficacious. The authors compare two groups of pregnant women in whom the muscular vascular tone of the cervix is abolished. The second group was treated with heparin. The results are statistically significant and prove that treatment with heparin is well based in cases of underdevelopment of the fetus when it is due to abnormalities in the maternal microscopic circulation (acute atherosis). They confirm that the enzyme, hormone and ultrasound parameters return to normal from the beginning of treatment with heparin.
使用肝素干预胎儿发育异常的出现（或纠正这种异常）是合乎逻辑的，但结果难以证明，因为在治疗最有可能有效的时候很难确定早期诊断。作者比较了两组宫颈肌肉血管张力消失的孕妇。第二组接受了肝素治疗。结果具有统计学意义，证明在胎儿发育不全是由母体微循环异常（急性动脉粥样硬化）引起的情况下，肝素治疗是有充分依据的。他们证实，从开始使用肝素治疗起，酶、激素和超声参数就恢复正常了。
