[Value of placental enzymes, endocrinologic parameters of pregnancy and placental perfusion in cases of intrauterine growth retardation].

The serum HCS concentration and urine estriol (E3) content was determined just before delivery in mature but intrauterine retarded and mature eutrophic cases. The hormonal parameters and the placental perfusion index (PPI) were determined in each case parallel. The mitochondrial glutamate dehydrogenase (GLDH) and the glycolytic lactate dehydrogenase (LDH) activity in the placentas were determined immediately after the placentas were born. Among the cases in which intrauterine retarded newborns were born the half of the women had gestosis during their pregnancy and the half had not any problem. It has been found that serum HCS concentration and urine E3 content were significantly lower in the pathologic groups compared to the control. The placental LDH activity significantly increased in both of the dysmature groups. The GLDH activity was normal in the toxemic cases but decreased significantly in the cases where the newborns were dysmature and the mother had no toxemia. There was a correlation between the serum HCS concentration and placental GLDH activity in non-toxemic cases. The perfusion was significantly lower in the toxemic cases only. At the same time there was no correlation between the placental perfusion and endocrine parameters or enzyme activities in both of the pathologic groups.