Zhang Chutian, Chen Shiya, Li Xiyu, Xu Qian, Lin Yao, Lin Fan, Yuan Mingzhou, Zi Yong, Cai Jing
Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
The Third Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China.
Biomed Pharmacother. 2022 Nov;155:113768. doi: 10.1016/j.biopha.2022.113768. Epub 2022 Sep 28.
Parkinson's disease (PD) is the second major progressive neurodegenerative disease, which critically impacts patients' quality of life. Based on genetics, animal models of genetic defects created by gene editing technology have clear advantages in reflecting PD's pathogenesis and pathological characteristics and exploring potential therapeutic targets for PD. In this review, we summarized animal models of genetic defects in various pathogenesis of PD, including α-synuclein abnormal encoding, autophagy-lysosome system defects, ubiquitin protease system defects, and mitochondria-related dysfunction, and discuss their respective advantages, limitations, and application directions to provide a reference for the application of animal models of PD and research on anti-PD therapy.
帕金森病（PD）是第二大主要的进行性神经退行性疾病，严重影响患者的生活质量。基于遗传学，利用基因编辑技术创建的基因缺陷动物模型在反映PD的发病机制和病理特征以及探索PD的潜在治疗靶点方面具有明显优势。在本综述中，我们总结了PD各种发病机制中的基因缺陷动物模型，包括α-突触核蛋白异常编码、自噬-溶酶体系统缺陷、泛素蛋白酶系统缺陷和线粒体相关功能障碍，并讨论了它们各自的优势、局限性和应用方向，为PD动物模型的应用及抗PD治疗研究提供参考。
