两种不同品系（C57BL/6J和杂交品系B6129SF1/J）的年轻雄性小鼠在选定行为测试中的比较：一项小规模研究。
Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests: a small scale study.
作者信息
Hansen Kristine Eraker Aasland, Hudecová Alexandra M, Haugen Fred, Skjerve Eystein, Ropstad Erik, Zimmer Karin E
机构信息
Section for Experimental Biomedicine, Department of Production Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.
Environmental Chemistry Department, Norwegian Institute for Air Research, Ås, Norway.
出版信息
Lab Anim Res. 2022 Oct 2;38(1):30. doi: 10.1186/s42826-022-00140-5.
BACKGROUND
All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J, and gained knowledge on their performance in three different behavioral tests; open field (OF) test, Barnes maze (BM) test and a restraint stress test.
RESULTS
We found that the young males of the C57BL/6J strain spent more time moving in the OF. In the BM, the hybrid covered less ground before reaching the goal box during the first three sessions, than the C57BL/6J. The hybrid left more fecal pellets than C57BL/6J both in OF and BM. During the stress test, the C57BL/6J had a lower corticosterone response than the hybrid.
CONCLUSIONS
Our findings indicate that the C57BL/6J has a presumably higher locomotor activity and/or explorative behavior than the hybrid, while the hybrid appeared more sensitive to stress.
背景
所有小鼠品系都有所不同，在选择一个品系进行大规模研究之前，应该先进行小规模研究。在本研究中，我们比较了两种小鼠品系C57BL/6J和杂交品系B6129SF1/J的年轻雄性小鼠，并了解了它们在三种不同行为测试中的表现；旷场（OF）试验、巴恩斯迷宫（BM）试验和束缚应激试验。
结果
我们发现C57BL/6J品系的年轻雄性小鼠在旷场中活动的时间更多。在巴恩斯迷宫试验中，在前三个试验阶段，杂交品系在到达目标箱之前覆盖的区域比C57BL/6J品系小。在旷场试验和巴恩斯迷宫试验中，杂交品系留下的粪便颗粒都比C57BL/6J品系多。在应激试验中，C57BL/6J品系的皮质酮反应比杂交品系低。
结论
我们的研究结果表明，C57BL/6J品系可能比杂交品系具有更高的运动活性和/或探索行为，而杂交品系似乎对应激更敏感。
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