harmacy Department, Hospital Universitario Virgen del Rocío, Sevilla. Spain..
harmacy Department, Hospital Bermingham, Donosti. Spain..
Farm Hosp. 2022 Jul 6;46(5):311-315.
Deprescribing is considered one of the main strategies available for preparing an individualized therapeutic plan in patients with multiple pathologies or complex chronic conditions. However, despite the practice has been in place for some years, there is a need for studies that support the achievement of satisfactory health outcomes, as well as tools that help implement deprescribing in routine clinical practice. The bjective of this project is to analyze the impact of reducing polypharmacy, through the LESS-CHRON deprescribing tool, on a population of elderly polymedicated patients with multiple conditions.
This will be a quasi-experimental, pre-and-post intervention multicenter cohort study. The variables to be analyzed will be divided into two large groups: those related to pharmacology and those related to health outcomes. They will be collected at baseline, at 3 and at 6-12 months. A first screening phase will be carried out to recruit candidate patients and obtain information about the identified deprescribing opportunities. The second phase will constitute the intervention phase, where the LESS-CHRON tool will be applied and the actual deprescribing of the drugs will be carried out.
LESS-CHRON has been proclaimed as a suitable deprescribing tool in clinical practice. Validation of LESS-CHRON will seek to show the results that can be achieved following the deprescribing of drugs, in addition to demonstrating that the tool can reliably be used by clinicians in their routine practice. On the other hand, the results of this project may provide information leading to improving or adapting the tool itself, giving rise to a second generation of more efficient version.
在患有多种疾病或复杂慢性病的患者中，减少用药（deprescribing）被认为是制定个体化治疗方案的主要策略之一。尽管该实践已经存在了一些年，但仍需要研究来支持实现令人满意的健康结果，并需要工具来帮助在常规临床实践中实施减少用药。本项目的目的是分析通过 LESS-CHRON 减少用药工具，对患有多种疾病的老年多用药患者人群的影响。
这将是一项准实验、干预前后的多中心队列研究。待分析的变量将分为两组：一组与药理学相关，另一组与健康结果相关。这些变量将在基线、3 个月和 6-12 个月时收集。将进行第一阶段筛选，以招募候选患者并获取关于已识别的减少用药机会的信息。第二阶段将构成干预阶段，将应用 LESS-CHRON 工具并实际减少药物。
LESS-CHRON 已被宣布为临床实践中合适的减少用药工具。LESS-CHRON 的验证将试图展示在减少用药后可以实现的结果，此外还证明该工具可以由临床医生在常规实践中可靠地使用。另一方面，该项目的结果可能提供有关改进或调整工具本身的信息，从而产生更高效的第二代版本。
