Section of Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands.
Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, UK.
Sleep. 2022 Dec 12;45(12). doi: 10.1093/sleep/zsac239.
Major hallmarks of functional loss, loss of metabolic and musculoskeletal health and (multi)morbidity with aging are associated with sleep disturbances. With poor sleep shifts in gut microbial composition commonly manifest, which could mediate the pro-inflammatory state between sleep disturbances and sarcopenia. This systematic review presents the recent evidence on how sleep disturbances throughout the lifespan associate with and contribute to gut microbial composition changes, proposing a mechanism to understand the etiology of sarcopenia through sleep disturbances. The relationship between disturbed sleep and clinically relevant gut microbiota composition on health aspects of aging is discussed. A search was performed in PubMed, Cochrane Library, Scopus, Web of Science using keywords including (microbio* OR microflora) AND (sleep OR sleep disorder). Six cross-sectional population-based studies and five experimental clinical trials investigating healthy individuals with ages ranging from 4 to 71 were included. The cross-sectional studies reported similarities in associations with sleep disturbance and gut microbial diversity. In older adults, shorter sleep duration is associated with an increase in pro-inflammatory bacteria whereas increasing sleep quality is positively associated with an increase of beneficial Verrucomicrobia and Lentisphaerae phyla. In young adults, the effect of sleep disruption on gut microbiome composition, specifically the ratio of beneficial Firmicutes over Bacteroidetes phyla, remains contradictory and unclear. The findings of this review warrant further research in the modulation of the gut microbiome linking poor sleep with muscle-catabolic consequences throughout the lifespan.
功能丧失、代谢和肌肉骨骼健康丧失以及衰老时的（多种）发病与睡眠障碍有关。随着睡眠的恶化，肠道微生物组成通常会发生变化，这可能是睡眠障碍与肌肉减少症之间炎症状态的中介。本系统综述介绍了睡眠障碍与肠道微生物组成变化相关的最新证据，提出了通过睡眠障碍来理解肌肉减少症病因的机制。讨论了睡眠障碍与临床上与衰老健康相关的肠道微生物组成之间的关系。在 PubMed、Cochrane 图书馆、Scopus 和 Web of Science 中使用包括 (microbio* 或 microflora) AND (睡眠或睡眠障碍) 的关键词进行了搜索。纳入了 6 项横断面人群研究和 5 项针对健康个体的实验性临床试验，年龄范围为 4 至 71 岁。横断面研究报告了与睡眠障碍和肠道微生物多样性的相似关联。在老年人中，较短的睡眠时间与促炎细菌的增加有关，而睡眠质量的提高则与有益的 Verrucomicrobia 和 Lentisphaerae 门的增加呈正相关。在年轻人中，睡眠中断对肠道微生物组组成的影响，特别是有益的厚壁菌门与拟杆菌门的比例，仍然存在矛盾和不清楚。本综述的研究结果表明，需要进一步研究调节肠道微生物组，将睡眠不佳与整个生命周期中的肌肉分解代谢后果联系起来。
