Department of Child Rehabilitation, Gansu Rehabilitation Center Hospital, Lanzhou, 15214075468, Gansu, China.
Sci Rep. 2024 Oct 6;14(1):23256. doi: 10.1038/s41598-024-75006-y.
Investigating the characteristics of the gut flora in children who go to bed early versus late. The study sample consisted of 88 healthy children aged 2-14 years, with an equal number of boys and girls. The researchers collected faecal samples from all participants and sequenced the genome of their gut flora. Findings indicate that beta diversity was statistically significant at the genus level for both the early and late sleeper groups (P = 0.045). Furthermore, alpha diversity indicators, including Simpson's index (P = 0.0011) and Shannon's index (P = 0.0013), exhibited higher values at the genus level. The differences observed in terms of species diversity, abundance, and metabolic pathways offer potential avenues for implementing pharmacological interventions aimed at addressing sleep disorders in children.
调查早睡和晚睡儿童的肠道菌群特征。研究样本包括 88 名年龄在 2-14 岁的健康儿童，其中男女各占一半。研究人员从所有参与者中收集粪便样本，并对其肠道菌群的基因组进行测序。研究结果表明，早睡和晚睡两组在属水平上的β多样性具有统计学意义（P=0.045）。此外，包括 Simpson 指数（P=0.0011）和 Shannon 指数（P=0.0013）在内的α多样性指标在属水平上也呈现出更高的值。在物种多样性、丰度和代谢途径方面观察到的差异为实施旨在解决儿童睡眠障碍的药物干预提供了潜在途径。
