IgA 肾病的肠道微生物组特征：观察性研究的定性和定量分析。
Gut Microbiome Characteristics in IgA Nephropathy: Qualitative and Quantitative Analysis from Observational Studies.
机构信息
Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Institute of Science, Technology and Humanities, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
出版信息
Front Cell Infect Microbiol. 2022 May 17;12:904401. doi: 10.3389/fcimb.2022.904401. eCollection 2022.
BACKGROUND
Recent data indicate the importance of gut-kidney axis in the pathogenesis of Immunoglobulin A nephropathy (IgAN). Growing evidence suggests the alterations of diversity and composition of gut microbiome among patients with IgAN, however, the details are not yet fully understood.
METHODS
Eligible studies comparing the gut microbiome between patients with IgAN and non-IgAN individuals were systematically searched from PubMed, Embase, Web of Science, Cochrane Library, China National Knowledge Infrastructure, and . The primary outcomes were alpha- and beta-diversity, and the differences in gut microbiota composition between patients with IgAN and non-IgAN persons. Qualitative analysis and meta-analysis were performed according to available data.
RESULTS
Eleven cross-sectional studies, including 409 patients with IgAN and 243 healthy controls, were enrolled. No significant differences in the diversity and enrichment of gut bacteria were found between IgAN and healthy individuals, whereas the beta-diversity consistently showed significant microbial dissimilarities among the two groups. , and were the dominant phyla, however, no significant differences were found between IgAN patients and healthy controls at the phylum level. The genera, and showed a higher proportion in patients with IgAN compared to healthy individuals, whereas showed a lower abundance according to meta-analysis. Qualitative analyses suggested that might be increased in IgAN patients; the genera, ,and , members of and families, were likely to have decreased abundances in patients with IgAN compared to healthy individuals.
CONCLUSION
Gut microbiota dysbiosis was demonstrated in IgAN, which might be involved in the pathogenesis of IgAN. Further studies are needed to confirm the findings of this study, due to the substantial heterogeneity.
SYSTEMATIC REVIEW REGISTRATION
https://www.crd.york.ac.uk/prospero/, identifier PROSPERO (CRD42022304034).
背景
最近的数据表明，肠道-肾脏轴在 IgA 肾病（IgAN）的发病机制中起着重要作用。越来越多的证据表明，IgAN 患者的肠道微生物组多样性和组成发生了改变，然而，其细节尚不完全清楚。
方法
从 PubMed、Embase、Web of Science、Cochrane Library、中国知网和万方数据库中系统地检索了比较 IgAN 患者和非 IgAN 个体肠道微生物组的合格研究。主要结果是 alpha 和 beta 多样性，以及 IgAN 和非 IgAN 个体肠道微生物组成的差异。根据可用数据进行定性分析和荟萃分析。
结果
共纳入 11 项横断面研究，包括 409 例 IgAN 患者和 243 例健康对照者。IgAN 患者和健康个体的肠道细菌多样性和丰度无显著差异，而 beta 多样性显示两组之间存在显著的微生物差异。 、 和 是主要的门，但在门水平上，IgAN 患者和健康对照组之间没有发现显著差异。与健康个体相比，IgAN 患者中 、 和 属的比例较高，而 属的丰度较低，Meta 分析显示。定性分析表明，IgAN 患者中 可能增加；与健康个体相比，IgAN 患者中 、 、 和 属，以及 科和 科的成员，其丰度可能降低。
结论
IgAN 存在肠道微生物失调，可能参与了 IgAN 的发病机制。由于存在很大的异质性，需要进一步的研究来证实本研究的结果。
系统评价注册
https://www.crd.york.ac.uk/prospero/，标识符 PROSPERO（CRD42022304034）。
Zotero 插件