Hartley Philip, Salmasi M Yousuf, Morosin Marco, Mensah Kwabena, Asimakopoulos George
Royal Brompton and Harefield NHS Foundation Trust, Department of Cardiothoracic Surgery, London, UK.
J Card Surg. 2022 Dec;37(12):4398-4405. doi: 10.1111/jocs.16985. Epub 2022 Oct 2.
The decision to conserve or replace the native aortic valve following acute type-A aortic dissection (ATAAD) is an area of cardiac surgery without standardized practice. This single-center retrospective study analysed the long-term performance of the native aortic valve and root following surgery for ATAAD.
Between 2009 and 2018 all cases ATAAD treated at Royal Brompton and Harefield NHS Foundation Trust were analysed. Patients were divided into two groups: (a) ascending aorta (interposition) graft (AAG) without valve replacement and (b) nonvalve-sparing aortic root replacement (ARR). Preoperative covariates were compared, as well as operative characteristics and postoperative complications. Long-term survival and echocardiographic outcomes were analysed using regression analysis.
In total, 116 patients were included: 63 patients in the AAG group and 53 patients in the ARR group. In patients where the native aortic valve was conserved, nine developed severe aortic regurgitation and two patients developed dilation of the aortic root requiring subsequent replacement during the follow-up period. Aortic regurgitation at presentation was not found to be associated with subsequent risk of developing severe aortic regurgitation or reintervention on the aortic valve. Overall mortality was observed to be significantly lower in patients undergoing AAG (17.5% vs. 41.5%, p = .004).
With careful patient selection, the native aortic root shows good long-term durability both in terms of valve competence and stable root dimensions after surgery for ATAAD. This study supports the consideration of conservation of the aortic valve during emergency surgery for type-A dissection, in the absence of a definitive indication for root replacement, including in cases where aortic regurgitation complicates the presentation.
急性A型主动脉夹层(ATAAD)后保留或置换天然主动脉瓣的决策是心脏外科领域中尚无标准化实践的一个方面。这项单中心回顾性研究分析了ATAAD手术后天然主动脉瓣和主动脉根部的长期性能。
对2009年至2018年间在皇家布朗普顿和哈雷菲尔德国民保健服务基金会信托医院接受治疗的所有ATAAD病例进行分析。患者分为两组:(a)升主动脉(插入)移植术(AAG)且未进行瓣膜置换,以及(b)非保留瓣膜的主动脉根部置换术(ARR)。比较术前协变量、手术特征和术后并发症。使用回归分析对长期生存率和超声心动图结果进行分析。
总共纳入116例患者:AAG组63例患者,ARR组53例患者。在保留天然主动脉瓣的患者中,9例出现严重主动脉瓣反流,2例患者在随访期间出现主动脉根部扩张,需要随后进行置换。发现就诊时的主动脉瓣反流与随后发生严重主动脉瓣反流或再次干预主动脉瓣的风险无关。观察到接受AAG手术的患者总体死亡率显著较低(17.5%对41.5%,p = 0.004)。
通过仔细选择患者,天然主动脉根部在ATAAD手术后的瓣膜功能和稳定的根部尺寸方面均显示出良好的长期耐久性。本研究支持在A型夹层急诊手术期间考虑保留主动脉瓣,前提是不存在明确的根部置换指征,包括主动脉瓣反流使病情复杂化的情况。