利用体内斑马鱼模型从川贝母鳞茎中发现具有抗炎活性的甾体生物碱苷。
Discovery of steroidal alkaloid glycosides from the bulbs of Fritillaria unibracteata with anti-inflammatory activities using an in vivo zebrafish model.
作者信息
Wang Shu-Hui, Wang Yu-Qi, Lv Tian, Ai Xiao-Ni, Kathy Tse Wai-Gaun, Liang Hong, Yang Tie-Chui, Zhang Qing-Ying, Tu Peng-Fei
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, People's Republic of China.
Nin Jiom Medicine Manufactory (H.K.) Limited, Hong Kong, 999077, People's Republic of China.
出版信息
Phytochemistry. 2022 Dec;204:113437. doi: 10.1016/j.phytochem.2022.113437. Epub 2022 Sep 20.
Nine undescribed steroidal alkaloid glycosides, unibrasolanosides A-F, unibraverazosides A-B, and unibratomatoside A, were isolated from the bulbs of Fritillaria unibracteata P. K. Hsiao & K. C. Hsia (Liliaceae). Their structures were elucidated by HRESIMS and 1D and 2D NMR data analyses as well as chemical methods and single-crystal X-ray diffraction analyses. Further investigation revealed that eight steroidal alkaloid glycosides displayed moderate anti-inflammatory activity in vivo in a CuSO-induced transgenic zebrafish model.
从川贝母（百合科）的鳞茎中分离出9种未描述的甾体生物碱苷，即单苞贝母苷A - F、单苞贝母新苷A - B和单苞贝母番茄苷A。通过高分辨电喷雾电离质谱（HRESIMS）、一维和二维核磁共振（NMR）数据分析以及化学方法和单晶X射线衍射分析确定了它们的结构。进一步研究表明，8种甾体生物碱苷在硫酸铜诱导的转基因斑马鱼模型中显示出中等程度的体内抗炎活性。
Zotero 插件