来自独头贝母鳞茎的甾体生物碱及其糖苷。
Steroidal alkaloids and their glycosides from the bulbs of Fritillaria unibracteata.
机构信息
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, People's Republic of China.
Nin Jiom Medicine Manufactory (H.K.) Limited, Hong Kong 999077, People's Republic of China.
出版信息
Steroids. 2022 May;181:108977. doi: 10.1016/j.steroids.2022.108977. Epub 2022 Feb 5.
Seven undescribed steroidal alkaloids, including two jervine-type steroidal alkaloids, fritiunibras A-B (1-2), and five cevanine-type steroidal alkaloid glycosides, fritiunibras C-G (3-7), along with six known cevanine-type steroidal alkaloids and their glycosides (8-13) were isolated from the bulbs of Fritillaria unibracteata Hsiao et K. C. Hsia. Their structures were determined by interpretation of comprehensive spectroscopic and single-crystal X-ray diffraction analysis. The absolute configurations of sugar moieties were determined by HPLC analysis and compared with standards after hydrolysis and derivatization. Furthermore, their inhibitory effects on NO production and cytotoxic activities were evaluated.
从独头贝母 Fritillaria unibracteata Hsiao et K. C. Hsia 的鳞茎中分离得到了 7 种未被描述的甾体生物碱，包括 2 种杰尔文型甾体生物碱，即 fritiunibras A-B（1-2），和 5 种塞瓦宁型甾体生物碱糖苷，即 fritiunibras C-G（3-7），以及 6 种已知的塞瓦宁型甾体生物碱及其糖苷（8-13）。通过全面的光谱和单晶 X 射线衍射分析解析了它们的结构。通过 HPLC 分析和水解及衍生化后与标准品比较确定了糖部分的绝对构型。此外，还评估了它们对 NO 产生的抑制作用和细胞毒性活性。
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