Niu Yan-Ning, Xia Xiao-Feng
Department of Teaching and Research, Nanjing Forestry University, Huaian, Jiangsu, 223003, People's Republic of China.
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, Jiangsu, 214122, People's Republic of China.
Org Biomol Chem. 2022 Oct 19;20(40):7861-7885. doi: 10.1039/d2ob01554d.
In recent years, isoquinoline-1,3(2,4)-dione compounds have attracted extensive attention from synthetic chemists, with the aim of finding simple, mild, green and efficient synthetic methods. In this review, we summarize the diverse range of synthetic methods employing acryloyl benzamides as key substrates to furnish isoquinoline-1,3-diones using different radical precursors, such as those containing carbon, sulphur, phosphorus, nitrogen, silicon and bromine. This will stimulate the interest of readers to engage in research in this field.
近年来，异喹啉-1,3(2,4)-二酮化合物吸引了合成化学家的广泛关注，目的是寻找简单、温和、绿色且高效的合成方法。在本综述中，我们总结了以丙烯酰基苯甲酰胺为关键底物，使用不同的自由基前体（如含碳、硫、磷、氮、硅和溴的自由基前体）来制备异喹啉-1,3-二酮的多种合成方法。这将激发读者对该领域研究的兴趣。
