Fu Shunlian, Sun Lisha, Chen Yiding, Zhou Qian, Yuan Lijun, Li Zinan, Chen Qiu
Hospital of Chengdu University of Traditional Chinese Medicine, chengdu, China.
Evid Based Complement Alternat Med. 2022 Sep 22;2022:6108772. doi: 10.1155/2022/6108772. eCollection 2022.
Due to the limited treatment options in antibiotic-associated diarrhea (AAD) in children, more effective treatments should be explored. Traditional Chinese medicine (TCM) has a long history in China, which has produced a pretty effect in clinical practice. Many randomized clinical trials (RCTs) have explored the effect of traditional Chinese medicine on treating AAD in children. However, there has been no systematic review or meta-analysis on the impact of TCM on AAD in children. The aim of this study was to systematically review RCTs on the effect of TCM in children with AAD.
RCTs in the past ten years on TCM for AAD in children were included. We searched Electronic databases as much as possible. This paper was registered in PROSPERO (CRD42022301034).
26 studies were included in this systematic review. 25 studies reported the effects of TCM interventions on the total effective rate (RR = 1.20, CI 1.16 to 1.24; < 0.001). 7 studies reported the effects of TCM interventions on the time to change the shape of feces (MD = -1.37, CI -1.67 to -1.07; < 0.001). 17 studies reported the effects of TCM interventions (MD = -1.43, CI -1.71 to -1.15; < 0.001). The pooled results showed that there were no significant differences between the two groups in CD3+, CD4+, CD8+, CD4 : CD8, time for bowel sounds to return to normal, hs-CRP, and IgM. There was a significant difference between the two groups in frequency of diarrhea on the third day after TCM intervention, vomiting improvement time, diamine oxidase, IL-8, TNF, IgA, IgG, and average hospital stay.
TCM interventions combined with conventional therapy can improve the therapeutic effect of AAD in children. However, future studies are still needed for the low methodological quality.
由于儿童抗生素相关性腹泻（AAD）的治疗选择有限，应探索更有效的治疗方法。中医在中国有着悠久的历史，在临床实践中产生了良好的效果。许多随机临床试验（RCT）探讨了中医治疗儿童AAD的效果。然而，尚未有关于中医对儿童AAD影响的系统评价或荟萃分析。本研究的目的是系统评价RCT关于中医对儿童AAD疗效的研究。
纳入过去十年中关于中医治疗儿童AAD的RCT。我们尽可能多地检索电子数据库。本文已在PROSPERO（CRD42022301034）注册。
本系统评价纳入26项研究。25项研究报告了中医干预对总有效率的影响（RR = 1.20，CI 1.16至1.24；P < 0.001）。7项研究报告了中医干预对粪便形状改变时间的影响（MD = -1.37，CI -1.67至-1.07；P < 0.001）。17项研究报告了中医干预的效果（MD = -1.43，CI -1.71至-1.15；P < 0.001）。汇总结果显示，两组在CD3 +、CD4 +、CD8 +、CD4∶CD8、肠鸣音恢复正常时间、hs-CRP和IgM方面无显著差异。两组在中医干预后第三天的腹泻频率、呕吐改善时间、二胺氧化酶、IL-8、TNF、IgA、IgG和平均住院时间方面存在显著差异。
中医干预联合传统疗法可提高儿童AAD的治疗效果。然而，由于方法学质量较低，仍需要未来的研究。
