糖尿病酮症酸中毒患儿抗生素的合理使用需要关注。
Rational use of antibiotics in children with diabetic ketoacidosis needs attention.
作者信息
Wang Xu
机构信息
Department of Endocrinology, Children's Hospital of Nanjing Medical University, Nanjing 210008, China.
出版信息
World J Clin Pediatr. 2022 Sep 9;11(5):405-407. doi: 10.5409/wjcp.v11.i5.405.
Diabetic ketoacidosis (DKA) in children may lead to acute kidney injury (AKI). Among 45 children with DKA in our center, eight cases had AKI on admission, and in one child, his kidney function did not recover until 3 mo after discharge. This child was treated with antibiotics (cephalosporin), and we cannot rule out delayed AKI recovery due to the combined effects of the drug and the disease. Pediatricians should be concerned about the impact of nephrotoxic drug and disease interactions on children's kidney function, and need to follow up children with DKA and AKI to determine the development of AKI.
儿童糖尿病酮症酸中毒（DKA）可能导致急性肾损伤（AKI）。在我们中心的45例DKA患儿中，8例入院时即存在AKI，其中1例患儿直到出院后3个月肾功能才恢复。该患儿接受了抗生素（头孢菌素）治疗，我们不能排除药物与疾病的联合作用导致AKI恢复延迟。儿科医生应关注肾毒性药物与疾病相互作用对儿童肾功能的影响，并且需要对DKA合并AKI的患儿进行随访，以确定AKI的发展情况。
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