Niu Yue, Zhang Qian, Wang Jiaojiao, Li Yanjie, Wang Xinhua, Bao Yan
Shanghai Collaborative Innovation Center of Agri-Seeds, Joint Center for Single Cell Biology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Front Plant Sci. 2022 Sep 14;13:994058. doi: 10.3389/fpls.2022.994058. eCollection 2022.
Vitamin E, also known as tocochromanol, is a lipid-soluble antioxidant that can only be produced by photosynthetic organisms in nature. Vitamin E is not only essential in human diets, but also required for plant environment adaptions. To synthesize vitamin E, specific prenyl groups needs to be incorporated with homogentisate as the first step of reaction. After decades of studies, an almost complete roadmap has been revealed for tocochromanol biosynthesis pathway. However, chlorophyll-derived prenyl precursors for synthesizing tocochromanols are still a mystery. In recent years, by employing forward genetic screening and genome-wide-association approaches, significant achievements were acquired in studying vitamin E. In this review, by summarizing the recent progresses in vitamin E, we provide to date the most updated whole view of vitamin E biosynthesis pathway. Also, we discussed about the role of vitamin E in plants stress response and its potential as signaling molecules.
维生素E，也被称为生育三烯酚，是一种脂溶性抗氧化剂，在自然界中只能由光合生物产生。维生素E不仅是人类饮食中必不可少的，也是植物适应环境所必需的。要合成维生素E，特定的异戊烯基需要与尿黑酸结合，这是反应的第一步。经过数十年的研究，生育三烯酚生物合成途径的几乎完整路线图已被揭示。然而，用于合成生育三烯酚的叶绿素衍生异戊烯基前体仍然是个谜。近年来，通过采用正向遗传筛选和全基因组关联方法，在维生素E研究方面取得了重大成果。在这篇综述中，通过总结维生素E的最新进展，我们提供了迄今为止维生素E生物合成途径的最新全景图。此外，我们还讨论了维生素E在植物应激反应中的作用及其作为信号分子的潜力。
