Benedet J L, Miller D M, Nickerson K G, Anderson G H
Am J Obstet Gynecol. 1987 Aug;157(2):268-73. doi: 10.1016/s0002-9378(87)80149-7.
The results after cryosurgical treatment of cervical intraepithelial neoplasia at 1, 5, and 10 years are reported. Ninety-four percent of the 1675 patients eligible for assessment at 1 year were successfully treated, with only 5.6% lost to follow-up. After 5 years, 14% of patients were lost to follow-up, but the corrected success rate remained essentially unchanged. No major differences in success rates were noted for the various histologic grades of cervical intraepithelial neoplasia treated. A small but definite percentage of patients developed further disease over the ensuing years, indicating the need for long-term, continued surveillance of these patients.
报告了宫颈上皮内瘤变冷冻治疗后1年、5年和10年的结果。1675例符合1年评估条件的患者中，94%得到成功治疗，仅有5.6%失访。5年后，14%的患者失访，但校正后的成功率基本保持不变。所治疗的不同组织学分级的宫颈上皮内瘤变的成功率未发现重大差异。在随后几年中，一小部分但确切比例的患者出现了进一步的病变，这表明需要对这些患者进行长期持续监测。
