Olatunbosun O A, Okonofua F E, Ayangade S O
Department of Obstetrics and Gynaecology, Faculty of Health Sciences, Obafemi Awolowo University, Ile-Ife, Nigeria.
Int J Gynaecol Obstet. 1992 Aug;38(4):305-10. doi: 10.1016/0020-7292(92)91023-h.
Over a 2-year period cryosurgery was used to treat 73 women who were diagnosed by colposcopy and histologic studies to have cervical intraepithelial neoplasia (CIN). Follow-up was achieved for 70% at 5 years, a significant attendance rate in a developing country. The primary cure rate was 88.5% at 1 year and 90% at 5 years (excluding those lost to follow-up) in all patients with different grades of CIN. The therapy was free of major complications and we found no adverse effect of cryosurgery on subsequent reproductive function in those desiring pregnancy. We conclude that cryosurgery has gained wide acceptance in our geographic area particularly because of its low cost, efficacy and preservation of fertility. For these reasons we would strongly recommend its use provided adequate attention is paid to meticulous pretreatment evaluation and long-term follow-up after therapy.
在两年时间里，冷冻手术被用于治疗73名经阴道镜检查和组织学研究诊断为宫颈上皮内瘤变（CIN）的女性。在一个发展中国家，5年的随访率达到了70%，这是一个相当可观的随访率。在所有不同级别CIN的患者中，1年时的初步治愈率为88.5%，5年时为90%（不包括失访者）。该治疗方法无重大并发症，并且我们发现冷冻手术对那些有怀孕意愿的患者的后续生殖功能没有不良影响。我们得出结论，冷冻手术在我们所在地区已得到广泛认可，特别是因为其成本低、疗效好以及对生育功能的保留。出于这些原因，我们强烈建议使用冷冻手术，前提是在治疗前要充分重视细致的评估，并在治疗后进行长期随访。
