Parchwani Deepak, Dholariya Sagar, Katoch Cds, Singh Ragini
Department of Biochemistry, All India Institute of Medical Sciences, Rajkot 360001, Gujarat, India.
Department of Pulmonary Medicine, All India Institute of Medical Sciences, Rajkot 360001, Gujarat, India.
World J Methodol. 2022 Sep 20;12(5):438-447. doi: 10.5662/wjm.v12.i5.438.
Growth differentiation factor (GDF)-15 is a member of a transforming growth factor-β cytokine superfamily that regulates metabolism and is released in response to inflammation, hypoxia and tissue injury. It has evolved as one of the most potent cytokines for predicting the severity of infections and inflammatory conditions, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
To investigate the utility of GDF-15 in predicting the severity of SARS-CoV-2 infection.
PubMed, Reference Citation Analysis, CNKI, and Goggle Scholar were explored by using related MeSH keywords and data such as the first author's name, study duration, type and place of study, sample size and subgroups of participants if any, serum/plasma GDF- 15 level in pg/mL, area under the curve and cut-off value in receiver operating characteristic analysis, method of measurement of GDF-15, and the main conclusion were extracted.
In all studies, the baseline GDF-15 level was elevated in SARS-CoV-2-infected patients, and it was significantly associated with severity, hypoxemia, viral load, and worse clinical consequences. In addition, GDF-15 levels were correlated with C-reactive protein, D-dimer, ferritin and procalcitonin, and it had superior discriminatory ability to detect severity and in-hospital mortality of SARS-CoV-2 infection. Hence, GDF-15 might be used to predict the severity and prognosis of hospitalized patients with SARS-CoV-2.
Serial estimation of GDF-15 levels in hospitalized patients with SARS-CoV-2 infection appeared to have useful prognostic value and GDF-15 can be considered a clinically prominent sepsis biomarker for SARS-CoV-2 infection.
生长分化因子（GDF）-15是转化生长因子-β细胞因子超家族的成员，可调节新陈代谢，并在炎症、缺氧和组织损伤时释放。它已成为预测感染和炎症性疾病严重程度的最有效细胞因子之一，如严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染。
研究GDF-15在预测SARS-CoV-2感染严重程度方面的作用。
通过使用相关医学主题词（MeSH）关键词以及第一作者姓名、研究持续时间、研究类型和地点、样本量以及参与者亚组（如有）、以pg/mL为单位的血清/血浆GDF-15水平、受试者工作特征分析中的曲线下面积和临界值、GDF-15的测量方法等数据，对PubMed、参考文献引用分析、中国知网和谷歌学术进行检索，并提取主要结论。
在所有研究中，SARS-CoV-2感染患者的基线GDF-15水平升高，且与疾病严重程度、低氧血症、病毒载量及更差的临床后果显著相关。此外，GDF-15水平与C反应蛋白、D-二聚体、铁蛋白和降钙素原相关，在检测SARS-CoV-2感染的严重程度和住院死亡率方面具有更好的鉴别能力。因此，GDF-15可用于预测SARS-CoV-2感染住院患者的严重程度和预后。
对SARS-CoV-2感染住院患者进行GDF-15水平的系列评估似乎具有有用的预后价值，GDF-15可被视为SARS-CoV-2感染临床上重要的脓毒症生物标志物。
