Yasmin Farah, Sahito Abdul Moiz, Mir Syeda Lamiya, Khatri Govinda, Shaikh Somina, Gul Ambresha, Hassan Syed Adeel, Koritala Thoyaja, Surani Salim
Department of Medicine, Dow University of Health Sciences, Karachi 74200, Pakistan.
Department of Medicine, People's University of Medical and Health Sciences, Nawabshah 67480, Pakistan.
World J Gastrointest Pathophysiol. 2022 Sep 22;13(5):128-142. doi: 10.4291/wjgp.v13.i5.128.
Inflammatory bowel disease (IBD) is an inflammatory disease of the gastrointestinal (GI) tract. It has financial and quality of life impact on patients. Although there has been a significant advancement in treatments, a considerable number of patients do not respond to it or have severe side effects. Therapeutic approaches such as electrical neuromodulation are being investigated to provide alternate options. Although bioelectric neuromodulation technology has evolved significantly in the last decade, sacral nerve stimulation (SNS) for fecal incontinence remains the only neuromodulation protocol commonly utilized use for GI disease. For IBD treatment, several electrical neuromodulation techniques have been studied, such as vagus NS, SNS, and tibial NS. Several animal and clinical experiments were conducted to study the effectiveness, with encouraging results. The precise underlying mechanisms of action for electrical neuromodulation are unclear, but this modality appears to be promising. Randomized control trials are required to investigate the efficacy of intrinsic processes. In this review, we will discuss the electrical modulation therapy for the IBD and the data pertaining to it.
炎症性肠病（IBD）是一种胃肠道（GI）的炎症性疾病。它对患者的经济状况和生活质量都有影响。尽管治疗方面有了显著进展，但仍有相当数量的患者对此无反应或出现严重副作用。诸如电神经调节等治疗方法正在研究中，以提供替代选择。尽管生物电神经调节技术在过去十年中有了显著发展，但用于治疗大便失禁的骶神经刺激（SNS）仍然是唯一常用于胃肠道疾病的神经调节方案。对于IBD治疗，已经研究了几种电神经调节技术，如迷走神经刺激、骶神经刺激和胫神经刺激。进行了多项动物和临床试验来研究其有效性，结果令人鼓舞。电神经调节的确切潜在作用机制尚不清楚，但这种方法似乎很有前景。需要进行随机对照试验来研究其内在过程的疗效。在这篇综述中，我们将讨论IBD的电调制疗法及其相关数据。
