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丙型肝炎病毒与肿瘤起始干细胞样细胞

HCV and tumor-initiating stem-like cells.

作者信息

Machida Keigo

机构信息

Department of Molecular Microbiology and Immunology, Southern California Research Center for ALPD and Cirrhosis, University of Southern California Keck School of Medicine, Los Angeles, CA, United States.

出版信息

Front Physiol. 2022 Sep 15;13:903302. doi: 10.3389/fphys.2022.903302. eCollection 2022.

DOI:10.3389/fphys.2022.903302
PMID:36187761
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9520593/
Abstract

Neoplasms contain tumor-initiating stem-like cells (TICs) that are characterized by increased drug resistance. The incidence of many cancer types have trended downward except for few cancer types, including hepatocellular carcinoma (HCC). Therefore mechanism of HCC development and therapy resistance needs to be understood. These multiple hits by hepatitis C virus (HCV) eventually promotes transformation and TIC genesis, leading to HCC development. This review article describes links between HCV-associated HCC and TICs. This review discusses 1) how HCV promotes genesis of TICs and HCC development; 2) how this process avails itself as a novel therapeutic target for HCC treatment; and 3) ten hall marks of TIC oncogenesis and HCC development as targets for novel therapeutic modalities.

摘要

肿瘤包含具有肿瘤起始能力的干细胞样细胞（TICs），其特征是耐药性增强。除了少数几种癌症类型（包括肝细胞癌（HCC））外，许多癌症类型的发病率都呈下降趋势。因此，需要了解HCC的发生发展机制以及治疗耐药性。丙型肝炎病毒（HCV）的这些多重打击最终促进了细胞转化和TIC的产生，导致HCC的发展。这篇综述文章描述了HCV相关HCC与TICs之间的联系。本综述讨论了：1）HCV如何促进TICs的产生和HCC的发展；2）这一过程如何成为HCC治疗的新靶点；3）作为新型治疗方式靶点的TIC肿瘤发生和HCC发展的十大特征。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/fbf4b1bebb0b/fphys-13-903302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/ba424b87522c/fphys-13-903302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/d26d7c78e049/fphys-13-903302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/e3e49afd34c0/fphys-13-903302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/a3405484fad4/fphys-13-903302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/fbf4b1bebb0b/fphys-13-903302-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/ba424b87522c/fphys-13-903302-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/d26d7c78e049/fphys-13-903302-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/e3e49afd34c0/fphys-13-903302-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/a3405484fad4/fphys-13-903302-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/575c/9520593/fbf4b1bebb0b/fphys-13-903302-g005.jpg

相似文献

[1]
HCV and tumor-initiating stem-like cells.

Front Physiol. 2022-9-15

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
High Prevalence of and Mutations in Brazilian HCC Tissues: Insights into Early Detection and Risk Stratification.

Int J Mol Sci. 2025-7-6

[2]
Geographic and Viral Etiology Patterns of Promoter and Exon 3 Mutations in Hepatocellular Carcinoma: A Comprehensive Review.

Int J Mol Sci. 2025-3-22

[3]
Serum CYFRA 21-1 and CK19-2G2 as Predictive Biomarkers of Response to Transarterial Chemoembolization in Hepatitis C-related Hepatocellular Carcinoma Among Egyptians: A Prospective Study.

J Clin Exp Hepatol. 2025

本文引用的文献

[1]
Long non-coding RNA placenta‑specific protein 2 regulates the chemosensitivity of cancer cells to cisplatin in hepatocellular carcinoma (HCC) by sponging microRNA-96 to upregulate X-linked inhibitor of apoptosis protein.

Bioengineered. 2022-4

[2]
Differential expression of long noncoding RNA in hepatocellular carcinoma on top of chronic HCV and HBV infections.

Clin Exp Hepatol. 2021-12

[3]
Overexpression of IncRNA TPT1-AS1 Suppresses Hepatocellular Carcinoma Cell Proliferation by Downregulating CDK2.

Crit Rev Eukaryot Gene Expr. 2022

[4]
Long non-coding RNA H19 as a biomarker for hepatocellular carcinoma.

Liver Int. 2022-6

[5]
Decoding the Roles of Long Noncoding RNAs in Hepatocellular Carcinoma.

Int J Mol Sci. 2021-3-19

[6]
lncRNA HAND2-AS1 overexpression inhibits cancer cell proliferation in hepatocellular carcinoma by downregulating RUNX2 expression.

J Clin Lab Anal. 2021-4

[7]
Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention.

Nat Rev Gastroenterol Hepatol. 2021-4

[8]
Etiology of Hepatocellular Carcinoma: Special Focus on Fatty Liver Disease.

Front Oncol. 2020-11-30

[9]
The Relevance of MicroRNAs in the Pathogenesis and Prognosis of HCV-Disease: The Emergent Role of miR-17-92 in Cryoglobulinemic Vasculitis.

Viruses. 2020-11-29

[10]
Molecular and Functional Roles of MicroRNAs in the Progression of Hepatocellular Carcinoma-A Review.

Int J Mol Sci. 2020-11-7

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