Monod Cécile, Kotzaeridi Grammata, Eppel Daniel, Linder Tina, Bozkurt Latife, Hösli Irene, Göbl Christian S, Tura Andrea
Department of Obstetrics and Gynaecology, Medical University of Vienna, Vienna, Austria.
Department of Obstetrics, University Hospital Basel, Basel, Switzerland.
Front Physiol. 2022 Sep 16;13:988361. doi: 10.3389/fphys.2022.988361. eCollection 2022.
Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) infection may negatively affect glucose metabolism. This study aims to assess glucose levels, prevalence of gestational diabetes mellitus (GDM) and perinatal outcome in women with history of COVID-19. To this purpose, a group of 65 patients with history of COVID-19 and 94 control patients were retrospectively recruited among pregnant women who attended the pregnancy outpatient department between 01/2020 and 02/2022. Glucose data from an oral glucose tolerance test (OGTT), GDM status and obstetric complications were assessed. We observed no differences in average ( = 0.37), fasting ( = 0.62) or post-load glucose concentrations (60 min: = 0.19; 120 min: = 0.95) during OGTT. A total of 15 (23.1%) women in the COVID-19 group and 18 (19.1%) women in the control group developed GDM ( = 0.55). Moreover, caesarean section rate, weight percentiles and pregnancy outcomes were comparable between the groups ( = 0.49). In conclusion, in this study we did not identify a possible impact of COVID-19 on glucose metabolism in pregnancy, especially with regard to glucose concentrations during the OGTT and prevalence of GDM.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染可能会对糖代谢产生负面影响。本研究旨在评估有新冠病毒病（COVID-19）病史的女性的血糖水平、妊娠期糖尿病（GDM）患病率及围产期结局。为此，在2020年1月至2022年2月期间到妊娠门诊就诊的孕妇中，回顾性招募了一组65例有COVID-19病史的患者和94例对照患者。评估了口服葡萄糖耐量试验（OGTT）的血糖数据、GDM状态和产科并发症。我们观察到在OGTT期间，平均血糖（P = 0.37）、空腹血糖（P = 0.62）或负荷后血糖浓度（60分钟：P = 0.19；120分钟：P = 0.95）无差异。COVID-19组共有15例（23.1%）女性和对照组18例（19.1%）女性发生GDM（P = 0.55）。此外，两组间剖宫产率、体重百分位数和妊娠结局具有可比性（P = 0.49）。总之，在本研究中，我们未发现COVID-19对妊娠糖代谢有潜在影响，尤其是在OGTT期间的血糖浓度和GDM患病率方面。
