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CEPsh神经胶质细胞的发育对于一般的AWC身份或AWC不对称性并非必需。

CEPsh glia development is not required for general AWC identity or AWC asymmetry.

作者信息

Xiong Rui, Hsieh Yi-Wen, Chuang Chiou-Fen

机构信息

Department of Biological Sciences, University of Illinois at Chicago, IL, USA.

Graduate Program in Neuroscience, University of Illinois at Chicago, IL, USA.

出版信息

MicroPubl Biol. 2022 Sep 15;2022. doi: 10.17912/micropub.biology.000636. eCollection 2022.

DOI:10.17912/micropub.biology.000636
PMID:36188097
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9523477/
Abstract

The VAB-3/Pax6 homeodomain protein was previously shown to play a role in both the development of cephalic sheath (CEPsh) glia and asymmetric differentiation of AWC olfactory neuron subtypes AWC /AWC . Here we show that is not required for the specification of general AWC identity. We also show that some mutant alleles with defective CEPsh glia development displayed wild-type AWC asymmetry. These results suggest that has separable roles in CEPsh glia development and AWC asymmetry. Together, our results suggest that general AWC identity and AWC asymmetry are not dependent on the development of CEPsh glia.

摘要

先前的研究表明，VAB-3/Pax6同源结构域蛋白在头部鞘（CEPsh）神经胶质细胞的发育以及AWC嗅觉神经元亚型AWC⁺/AWC⁻的不对称分化中均发挥作用。在此我们表明，对于一般AWC身份的确定，VAB-3并非必需。我们还表明，一些具有缺陷的CEPsh神经胶质细胞发育的VAB-3突变等位基因表现出野生型的AWC不对称性。这些结果表明，VAB-3在CEPsh神经胶质细胞发育和AWC不对称性中具有可分离的作用。总之，我们的结果表明，一般AWC身份和AWC不对称性并不依赖于CEPsh神经胶质细胞的发育。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2b91/9523477/241eca389b90/25789430-2022-micropub.biology.000636.jpg

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