Roy Bipradas, Runa Sadia Afrin
Department of Physiology, Wayne State University, Detroit, MI 48201, United States.
Division of Hypertension and Vascular Research, Department of Internal Medicine, Henry Ford Health System, Detroit, MI 48202, United States.
World J Virol. 2022 Sep 25;11(5):252-274. doi: 10.5501/wjv.v11.i5.252.
Since the discovery of the coronavirus disease 2019 outbreak, a vast majority of studies have been carried out that confirmed the worst outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in people with preexisting health conditions, including diabetes, obesity, hypertension, cancer, and cardiovascular diseases. Likewise, diabetes itself is one of the leading causes of global public health concerns that impose a heavy global burden on public health as well as socio-economic development. Both diabetes and SARS-CoV-2 infection have their independent ability to induce the pathogenesis and severity of multi-system organ failure, while the co-existence of these two culprits can accelerate the rate of disease progression and magnify the severity of the disease. However, the exact pathophysiology of multi-system organ failure in diabetic patients after SARS-CoV-2 infection is still obscure. This review summarized the organ-specific possible molecular mechanisms of SARS-CoV-2 and diabetes-induced pathophysiology of several diseases of multiple organs, including the lungs, heart, kidneys, brain, eyes, gastrointestinal system, and bones, and sub-sequent manifestation of multi-system organ failure.
自2019年冠状病毒病疫情爆发以来，大量研究证实，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染在患有糖尿病、肥胖症、高血压、癌症和心血管疾病等基础疾病的人群中会导致最严重的后果。同样，糖尿病本身也是全球公共卫生关注的主要原因之一，给全球公共卫生以及社会经济发展带来了沉重负担。糖尿病和SARS-CoV-2感染都有独立诱发多系统器官衰竭的发病机制和严重程度的能力，而这两个致病因素并存会加速疾病进展速度并加重疾病严重程度。然而，SARS-CoV-2感染后糖尿病患者多系统器官衰竭的确切病理生理学仍不清楚。本综述总结了SARS-CoV-2和糖尿病诱发多器官多种疾病病理生理学的器官特异性可能分子机制，包括肺、心脏、肾脏、大脑、眼睛、胃肠道系统和骨骼，以及随后多系统器官衰竭的表现。
