Mirmohammadi S, Kianmehr A, Arefi M, Mahrooz A
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
New Microbes New Infect. 2020 Nov;38:100792. doi: 10.1016/j.nmni.2020.100792. Epub 2020 Oct 17.
Since its emergence, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide, and led to ever-increasing mortality. SARS-CoV-2 infection perturbs the function of the body's vital organs, making patients of all ages susceptible to the disease. Nevertheless, individuals developing critical illness with poor outcomes were mostly the elderly and people with co-morbid conditions, who constituted the vast majority of coronavirus disease 2019 (COVID-19) fatalities. Complications of COVID-19 mostly involve the respiratory, renal and cardiovascular systems, and in severe cases secondary infections leading to pneumonia and acute respiratory distress syndrome, which may precede the death of the patient. Multi-organ failure in individuals with COVID-19 could be a consequence of their co-morbidities. A patient's pre-existing conditions may affect the disease prognosis, requiring immediate attention to accurately detect and evaluate them in SARS-CoV-2-infected individuals. This review addresses several issues in relation to manifestations of the body's vital organs along with potential diagnostic blood factors in SARS-CoV-2 infection. It is hoped that the review will lead to more comprehensive understanding of this complex disease.
自出现以来，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已在全球范围内传播，并导致死亡率不断上升。SARS-CoV-2感染扰乱人体重要器官的功能，使各年龄段的患者都易患该疾病。然而，发展为危重病且预后不良的个体大多是老年人和患有合并症的人，他们构成了2019冠状病毒病（COVID-19）死亡病例的绝大多数。COVID-19的并发症大多累及呼吸、肾脏和心血管系统，严重时继发感染导致肺炎和急性呼吸窘迫综合征，这可能先于患者死亡。COVID-19患者的多器官衰竭可能是其合并症的结果。患者的既往病史可能影响疾病预后，需要立即关注以准确检测和评估SARS-CoV-2感染个体中的这些情况。本综述探讨了与SARS-CoV-2感染时人体重要器官表现以及潜在诊断血液指标相关的几个问题。希望该综述能增进对这种复杂疾病的全面了解。
