Juneja Deven, Gupta Anish, Kataria Sahil, Singh Omender
Institute of Critical Care Medicine, Max Super Speciality Hospital, Saket, New Delhi 110017, India.
World J Virol. 2022 Sep 25;11(5):300-309. doi: 10.5501/wjv.v11.i5.300.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the most dreadful viruses the mankind has witnessed. It has caused world-wide havoc and wrecked human life. In our quest to find therapeutic options to counter this threat, several drugs have been tried, with varying success. Certain agents like corticosteroids, some anti-virals and immunosuppressive drugs have been found useful in improving clinical outcomes. Vitamin C, a water-soluble vitamin with good safety profile, has been tried to reduce progression and im-prove outcomes of patients with coronavirus disease 2019 (COVID-19). Because of its anti-oxidant and immunomodulatory properties, the role of vitamin C has expanded well beyond the management of scurvy and it is increasingly been employed in the treatment of critically ill patients with sepsis, septic shock, acute pancreatitis and even cancer. However, in spite of many case series, observational studies and even randomised control trials, the role of vitamin C remains ambiguous. In this review, we will be discussing the scientific rationale and the current clinical evidence for using high dose vitamin C in the management of COVID-19 patients.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）已成为人类所见证的最可怕的病毒之一。它在全球范围内造成了严重破坏，危及人类生命。在我们寻求对抗这一威胁的治疗方案的过程中，已经尝试了多种药物，效果各异。某些药物，如皮质类固醇、一些抗病毒药物和免疫抑制药物，已被证明有助于改善临床结果。维生素C是一种具有良好安全性的水溶性维生素，已被尝试用于降低2019冠状病毒病（COVID-19）患者的病情进展并改善其预后。由于其抗氧化和免疫调节特性，维生素C的作用已远远超出了坏血病的治疗范畴，越来越多地被用于治疗脓毒症、感染性休克、急性胰腺炎甚至癌症的重症患者。然而，尽管有许多病例系列研究、观察性研究甚至随机对照试验，但维生素C的作用仍不明确。在这篇综述中，我们将讨论在COVID-19患者管理中使用高剂量维生素C的科学依据和当前临床证据。
