Ortelli Paola, Ferrazzoli Davide, Maestri Roberto, Saltuari Leopold, Kofler Markus, Alibardi Alessia, Koch Giacomo, Spampinato Danny, Castagna Anna, Sebastianelli Luca, Versace Viviana
Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Italy.
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituti Clinici Scientifici Maugeri, Pavia, Italy.
Front Rehabil Sci. 2021 Sep 8;2:720184. doi: 10.3389/fresc.2021.720184. eCollection 2021.
Implicit and explicit motor learning processes work interactively in everyday life to promote the creation of highly automatized motor behaviors. The cerebellum is crucial for motor sequence learning and adaptation, as it contributes to the error correction and to sensorimotor integration of on-going actions. A non-invasive cerebellar stimulation has been demonstrated to modulate implicit motor learning and adaptation. The present study aimed to explore the potential role of cerebellar theta burst stimulation (TBS) in modulating explicit motor learning and adaptation, in healthy subjects. Cerebellar TBS will be applied immediately before the learning phase of a computerized task based on a modified Serial Reaction Time Task (SRTT) paradigm. Here, we present a study protocol aimed at evaluating the behavioral effects of continuous (cTBS), intermittent TBS (iTBS), or sham Theta Burst Stimulation (TBS) on four different conditions: learning, adaptation, delayed recall and re-adaptation of SRTT. We are confident to find modulation of SRTT performance induced by cerebellar TBS, in particular, processing acceleration and reduction of error in all the conditions induced by cerebellar iTBS, as already known for implicit processes. On the other hand, we expect that cerebellar cTBS could induce opposite effects. Results from this protocol are supposed to advance the knowledge about the role of non-invasive cerebellar modulation in neurorehabilitation, providing clinicians with useful data for further exploiting this technique in different clinical conditions.
在日常生活中,内隐和外显运动学习过程相互作用,以促进高度自动化运动行为的形成。小脑对于运动序列学习和适应至关重要,因为它有助于错误纠正和正在进行动作的感觉运动整合。已证明非侵入性小脑刺激可调节内隐运动学习和适应。本研究旨在探讨小脑theta爆发刺激(TBS)在健康受试者中调节外显运动学习和适应的潜在作用。小脑TBS将在基于改良序列反应时任务(SRTT)范式的计算机化任务学习阶段之前立即应用。在此,我们提出一项研究方案,旨在评估连续(cTBS)、间歇性TBS(iTBS)或假theta爆发刺激(TBS)对四种不同条件下SRTT的学习、适应、延迟回忆和重新适应的行为影响。我们有信心发现小脑TBS引起的SRTT表现的调节,特别是,如内隐过程中已知的那样,小脑iTBS在所有条件下引起的处理加速和错误减少。另一方面,我们预计小脑cTBS可能会产生相反的效果。该方案的结果应能推进关于非侵入性小脑调节在神经康复中的作用的知识,为临床医生提供有用的数据,以便在不同临床情况下进一步利用该技术。
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