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测试显性运动学习-小脑θ波爆发刺激的实验方案

Experimental Protocol to Test Explicit Motor Learning-Cerebellar Theta Burst Stimulation.

作者信息

Ortelli Paola, Ferrazzoli Davide, Maestri Roberto, Saltuari Leopold, Kofler Markus, Alibardi Alessia, Koch Giacomo, Spampinato Danny, Castagna Anna, Sebastianelli Luca, Versace Viviana

机构信息

Department of Neurorehabilitation, Hospital of Vipiteno (SABES-ASDAA), Vipiteno-Sterzing, Italy.

Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituti Clinici Scientifici Maugeri, Pavia, Italy.

出版信息

Front Rehabil Sci. 2021 Sep 8;2:720184. doi: 10.3389/fresc.2021.720184. eCollection 2021.


DOI:10.3389/fresc.2021.720184
PMID:36188833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9397715/
Abstract

Implicit and explicit motor learning processes work interactively in everyday life to promote the creation of highly automatized motor behaviors. The cerebellum is crucial for motor sequence learning and adaptation, as it contributes to the error correction and to sensorimotor integration of on-going actions. A non-invasive cerebellar stimulation has been demonstrated to modulate implicit motor learning and adaptation. The present study aimed to explore the potential role of cerebellar theta burst stimulation (TBS) in modulating explicit motor learning and adaptation, in healthy subjects. Cerebellar TBS will be applied immediately before the learning phase of a computerized task based on a modified Serial Reaction Time Task (SRTT) paradigm. Here, we present a study protocol aimed at evaluating the behavioral effects of continuous (cTBS), intermittent TBS (iTBS), or sham Theta Burst Stimulation (TBS) on four different conditions: learning, adaptation, delayed recall and re-adaptation of SRTT. We are confident to find modulation of SRTT performance induced by cerebellar TBS, in particular, processing acceleration and reduction of error in all the conditions induced by cerebellar iTBS, as already known for implicit processes. On the other hand, we expect that cerebellar cTBS could induce opposite effects. Results from this protocol are supposed to advance the knowledge about the role of non-invasive cerebellar modulation in neurorehabilitation, providing clinicians with useful data for further exploiting this technique in different clinical conditions.

摘要

在日常生活中,内隐和外显运动学习过程相互作用,以促进高度自动化运动行为的形成。小脑对于运动序列学习和适应至关重要,因为它有助于错误纠正和正在进行动作的感觉运动整合。已证明非侵入性小脑刺激可调节内隐运动学习和适应。本研究旨在探讨小脑theta爆发刺激(TBS)在健康受试者中调节外显运动学习和适应的潜在作用。小脑TBS将在基于改良序列反应时任务(SRTT)范式的计算机化任务学习阶段之前立即应用。在此,我们提出一项研究方案,旨在评估连续(cTBS)、间歇性TBS(iTBS)或假theta爆发刺激(TBS)对四种不同条件下SRTT的学习、适应、延迟回忆和重新适应的行为影响。我们有信心发现小脑TBS引起的SRTT表现的调节,特别是,如内隐过程中已知的那样,小脑iTBS在所有条件下引起的处理加速和错误减少。另一方面,我们预计小脑cTBS可能会产生相反的效果。该方案的结果应能推进关于非侵入性小脑调节在神经康复中的作用的知识,为临床医生提供有用的数据,以便在不同临床情况下进一步利用该技术。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6868/9397715/79225935d549/fresc-02-720184-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6868/9397715/adcaa2f22d2b/fresc-02-720184-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6868/9397715/79225935d549/fresc-02-720184-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6868/9397715/adcaa2f22d2b/fresc-02-720184-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6868/9397715/79225935d549/fresc-02-720184-g0002.jpg

相似文献

[1]
Experimental Protocol to Test Explicit Motor Learning-Cerebellar Theta Burst Stimulation.

Front Rehabil Sci. 2021-9-8

[2]
Improving visuo-motor learning with cerebellar theta burst stimulation: Behavioral and neurophysiological evidence.

Neuroimage. 2020-3

[3]
Cerebellar transcranial magnetic stimulation in psychotic disorders: intermittent, continuous, and sham theta-burst stimulation on time perception and symptom severity.

Front Psychiatry. 2023-11-13

[4]
Intermittent Cerebellar Theta Burst Stimulation Improves Visuo-motor Learning in Stroke Patients: a Pilot Study.

Cerebellum. 2020-10

[5]
The After-Effects of Theta Burst Stimulation Over the Cortex of the Suprahyoid Muscle on Regional Homogeneity in Healthy Subjects.

Front Behav Neurosci. 2019-3-1

[6]
Changes in intracortical circuits of the human motor cortex following theta burst stimulation of the lateral cerebellum.

Clin Neurophysiol. 2008-11

[7]
Alterations of the amplitude of low-frequency fluctuation in healthy subjects with theta-burst stimulation of the cortex of the suprahyoid muscles.

Neuroscience. 2017-9-23

[8]
Cerebellar continuous theta-burst stimulation affects motor learning of voluntary arm movements in humans.

Eur J Neurosci. 2013-10-22

[9]
Reproducibility of cortical response modulation induced by intermittent and continuous theta-burst stimulation of the human motor cortex.

Brain Stimul. 2021

[10]
Bilateral sequential motor cortex stimulation and skilled task performance with non-dominant hand.

Clin Neurophysiol. 2017-5

引用本文的文献

[1]
Exploring the Therapeutic Effects and Mechanisms of Transcranial Alternating Current Stimulation on Improving Walking Ability in Stroke Patients via Modulating Cerebellar Gamma Frequency Band-a Narrative Review.

Cerebellum. 2024-8

本文引用的文献

[1]
The Cerebro-Cerebellum as a Locus of Forward Model: A Review.

Front Syst Neurosci. 2020-4-9

[2]
Improving visuo-motor learning with cerebellar theta burst stimulation: Behavioral and neurophysiological evidence.

Neuroimage. 2020-3

[3]
The Effect of Cerebellar Transcranial Direct Current Stimulation on Motor Learning: A Systematic Review of Randomized Controlled Trials.

Front Hum Neurosci. 2019-10-4

[4]
The importance of different learning stages for motor sequence learning after stroke.

Hum Brain Mapp. 2020-1

[5]
The super-learning hypothesis: Integrating learning processes across cortex, cerebellum and basal ganglia.

Neurosci Biobehav Rev. 2019-2-18

[6]
Improvement of gait and balance by non-invasive brain stimulation: its use in rehabilitation.

Expert Rev Neurother. 2019-1-7

[7]
Non-invasive brain stimulation for fine motor improvement after stroke: a meta-analysis.

Eur J Neurol. 2018-5-9

[8]
Basal ganglia and beyond: The interplay between motor and cognitive aspects in Parkinson's disease rehabilitation.

Neurosci Biobehav Rev. 2018-5-4

[9]
Closing the Loop: From Motor Neuroscience to Neurorehabilitation.

Annu Rev Neurosci. 2018-4-30

[10]
Therapeutic Use of Non-invasive Brain Stimulation in Dystonia.

Front Neurosci. 2017-7-25

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