a Centre for Neuromuscular and Neurological Disorders, Perron Institute for Neurological and Translational Science , University of Western Australia , Nedlands , Australia.
Expert Rev Neurother. 2019 Feb;19(2):133-144. doi: 10.1080/14737175.2019.1564042. Epub 2019 Jan 7.
Gait and balance impairments are common in many neurological disorders and among the elderly, are often difficult to treat, and have a significant effect on quality of life. Areas covered: Non-invasive brain stimulation (NIBS) technologies have been recognized for their therapeutic potential in various neurologic and psychiatric disorders. There is increasing interest in treatment of gait and balance impairment using newer modalities such as NIBS. Most therapeutic trials so far have been of small size and heterogeneous in design and stimulus parameters. Several controlled trials have begun to provide evidence for short-term improvement of gait and balance in some neurological disorders such as stroke and Parkinson's Disease. Trials in other neurological disorders are few and none in aged related impairment of gait and balance. Expert commentary: Large, well-designed clinical trials are needed to corroborate the early positive findings and confirm its durability and the overall clinical relevance.
步态和平衡障碍在许多神经障碍和老年人中很常见，通常难以治疗，对生活质量有重大影响。
非侵入性脑刺激 (NIBS) 技术已被公认为在各种神经和精神疾病中的治疗潜力。人们越来越感兴趣地使用新的方式，如 NIBS，来治疗步态和平衡障碍。到目前为止，大多数治疗试验的规模较小，设计和刺激参数各不相同。一些对照试验已经开始为一些神经障碍（如中风和帕金森病）中的步态和平衡的短期改善提供证据。在其他神经障碍中进行的试验很少，在与年龄相关的步态和平衡障碍中则没有。
需要进行大型、精心设计的临床试验来证实早期的积极发现，并确认其耐久性和整体临床相关性。
