Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, China.
Front Immunol. 2022 Sep 16;13:991044. doi: 10.3389/fimmu.2022.991044. eCollection 2022.
In the early 2000s, caspase-1, an important molecule that has been shown to be involved in the regulation of inflammation, cell survival and diseases, was given a new function: regulating a new mode of cell death that was later defined as pyroptosis. Since then, the inflammasome, the inflammatory caspases (caspase-4/5/11) and their substrate gasdermins (gasdermin A, B, C, D, E and DFNB59) has also been reported to be involved in the pyroptotic pathway, and this pathway is closely related to the development of various diseases. In addition, important apoptotic effectors caspase-3/8 and granzymes have also been reported to b involved in the induction of pyroptosis. In our article, we summarize findings that help define the roles of inflammasomes, inflammatory caspases, gasdermins, and other mediators of pyroptosis, and how they determine cell fate and regulate disease progression.
在 21 世纪初，caspase-1，一种被证明参与炎症、细胞存活和疾病调节的重要分子，被赋予了一个新的功能：调节一种后来被定义为细胞焦亡的新的细胞死亡方式。此后，炎症小体、炎性半胱天冬酶（caspase-4/5/11）及其底物 gasdermins（gasdermin A、B、C、D、E 和 DFNB59）也被报道参与细胞焦亡途径，该途径与各种疾病的发展密切相关。此外，重要的凋亡效应子 caspase-3/8 和颗粒酶也被报道参与细胞焦亡的诱导。在我们的文章中，我们总结了有助于确定炎症小体、炎性半胱天冬酶、gasdermins 和其他细胞焦亡介质的作用以及它们如何决定细胞命运和调节疾病进展的发现。
