Oechsli F W, Seltzer C C, van den Berg B J
Ann Allergy. 1987 Aug;59(2):135-40.
The data from a longitudinal study involving 1,445 white boys and girls from the San Francisco Bay area revealed a significant association between the adoption of cigarette smoking in adolescents with a history of either asthma or bronchitis in childhood and in early and middle teenage years. The association, present in both sexes, is stronger for bronchitis than for asthma, with the strength and direction of the association unaffected by such potentially confounding variables as parental smoking, socioeconomic status, psychosocial traits, etc. Age of onset of asthma (primarily in early childhood) preceded the commencement of smoking in 90% of subjects, indicating that cigarette smoking is not causally related to the development of childhood and adolescent asthma. With respect to bronchitis, however, as a result of the data on age of onset and the temporal relationship with the adoption of smoking, the possibility that cigarette smoking among adolescents may contribute to bronchitis cannot be dismissed.
一项针对旧金山湾区1445名白人男孩和女孩的纵向研究数据显示，童年时期、青少年早期和中期有哮喘或支气管炎病史的青少年吸烟之间存在显著关联。这种关联在男女中都存在，支气管炎患者的关联比哮喘患者更强，且关联的强度和方向不受父母吸烟、社会经济地位、心理社会特征等潜在混杂变量的影响。90%的受试者哮喘发病年龄（主要在幼儿期）早于开始吸烟的年龄，这表明吸烟与儿童和青少年哮喘的发生没有因果关系。然而，就支气管炎而言，根据发病年龄数据以及与吸烟开始时间的时间关系，青少年吸烟可能导致支气管炎的可能性不能排除。
