Fournier L, Fournier E, Lecorsier A
Ann Med Interne (Paris). 1987;138(3):169-72.
Lymphocytic NTE activity was measured after intoxication by organo phosphorus compounds and in chronic alcoholics at the beginning of alcohol withdrawal. The results showed a rapid fall in lymphocytic NTE activity; neuropathy developed when the inhibition was 75 p. 100 or more. In chronic alcoholics, the fall in NTE activity is a new concept which must be taken into account when considering the causal factors of neurotoxicity in exposed professions and in patients taking potentially neurotoxic drugs. The NTE may be a useful parameter to demonstrate the toxic origin of chronic neuropathies, especially those caused by drugs. The capacity for lymphocytic NTE activity to return to normal seems to be different in acute, compared with chronic, intoxications.
在有机磷化合物中毒后以及慢性酒精中毒者戒酒初期，对淋巴细胞神经毒性酯酶（NTE）活性进行了测定。结果显示淋巴细胞NTE活性迅速下降；当抑制率达到75%或更高时会出现神经病变。在慢性酒精中毒者中，NTE活性下降是一个新的概念，在考虑接触职业中神经毒性的因果因素以及服用潜在神经毒性药物的患者时必须予以考虑。NTE可能是一个有用的参数，可用于证明慢性神经病变的毒性起源，尤其是由药物引起的神经病变。与慢性中毒相比，急性中毒时淋巴细胞NTE活性恢复正常的能力似乎有所不同。
