Food College, Northeast Agricultural University, No.600 Changjiang St., Xiangfang Dist, 150030 Harbin, China; Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, No. 600 Changjiang St., Xiangfang Dist, 150030 Harbin, China.
Food College, Northeast Agricultural University, No.600 Changjiang St., Xiangfang Dist, 150030 Harbin, China; Key Laboratory of Dairy Science, Ministry of Education, Northeast Agricultural University, No. 600 Changjiang St., Xiangfang Dist, 150030 Harbin, China.
Food Res Int. 2022 Nov;161:111872. doi: 10.1016/j.foodres.2022.111872. Epub 2022 Aug 27.
This study aimed to identify differences of lipidome and fatty acid composition among human, bovine and caprine milk fat globule membrane (MFGM) using a lipidomics approach. In total, 11 lipid classes were determined, including PC, PE, SM, PG, PI, PS, Cer, PA, HexCer, HexCer and CL. Using positive and negative ionization modes, 73 and 156 common significantly differential lipid species were identified in three typical MFGM. The oleic acid (C18:1) was the dominant fatty acid in human (28.29 ± 0.04 g/100 g) and caprine (35.71 ± 0.02 g/100 g) MFGM, whereas Palmitic acid (C16:0, 29.13 ± 0.07 g/100 g) was the dominant fatty acid in bovine MFGM. In addition, there was no significant difference in long chain fatty acids between human MFGM and caprine milk. Overall, the results provide essential insights into differential lipids characterization in MFGM, along with a theoretical basis for the design of new infant formula.
本研究旨在采用脂质组学方法鉴定人乳、牛乳和羊乳脂肪球膜（MFGM）中的脂质组和脂肪酸组成的差异。共鉴定出 11 种脂质类，包括 PC、PE、SM、PG、PI、PS、Cer、PA、HexCer、HexCer 和 CL。使用正离子和负离子模式，在三种典型的 MFGM 中鉴定出 73 种和 156 种常见的差异显著的脂质种类。油酸（C18:1）是人乳（28.29±0.04g/100g）和羊乳（35.71±0.02g/100g）MFGM 中的主要脂肪酸，而棕榈酸（C16:0，29.13±0.07g/100g）是牛乳 MFGM 中的主要脂肪酸。此外，人乳 MFGM 和羊乳的长链脂肪酸没有显著差异。总的来说，这些结果为人乳 MFGM 中差异脂质的特征提供了重要的见解，并为新的婴儿配方奶粉的设计提供了理论基础。
