血小板衍生的外泌体可诱导人子宫内膜细胞增殖和伤口愈合。
Platelet-derived exosomes induce cell proliferation and wound healing in human endometrial cells.
作者信息
Miller Colleen M, L Enninga Elizabeth Ann, Rizzo Skylar A, Phillipps Jordan, Guerrero-Cazares Hugo, Destephano Christopher C, Peterson Timothy E, Stalboerger Paul G, Behfar Atta, Khan Zaraq
机构信息
Division of Reproductive Endocrinology & Infertility, Mayo Clinic, Rochester, MN 55905, USA.
Division of Immunology & Obstetrics & Gynecology, Mayo Clinic, Rochester, MN 55905, USA.
出版信息
Regen Med. 2022 Nov;17(11):805-817. doi: 10.2217/rme-2022-0095. Epub 2022 Oct 4.
To investigate the regenerative effects of a platelet-derived purified exosome product (PEP) on human endometrial cells. Endometrial adenocarcinoma cells (HEC-1A), endometrial stromal cells (T HESC) and menstrual blood-derived stem cells (MenSC) were assessed for exosome absorption and subsequent changes in cell proliferation and wound healing properties over 48 h. Cell proliferation increased in PEP treated T HESC (p < 0.0001) and MenSC (p < 0.001) after 6 h and in HEC-1A (p < 0.01) after 12 h. PEP improved wound healing after 6 h in HEC-1A (p < 0.01) and MenSC (p < 0.0001) and in T HESC between 24 and 36 h (p < 0.05). PEP was absorbed by three different endometrial cell types. PEP treatment increased cell proliferation and wound healing capacity.
为研究血小板衍生纯化外泌体产品（PEP）对人子宫内膜细胞的再生作用。评估子宫内膜腺癌细胞（HEC-1A）、子宫内膜基质细胞（T HESC）和月经血源性干细胞（MenSC）对外泌体的摄取情况，以及在48小时内细胞增殖和伤口愈合特性的后续变化。PEP处理后，T HESC（p < 0.0001）和MenSC（p < 0.001）在6小时后细胞增殖增加，HEC-1A在12小时后细胞增殖增加（p < 0.01）。在HEC-1A（p < 0.01）和MenSC（p < 0.0001）中，PEP在6小时后改善了伤口愈合，在T HESC中，在24至36小时之间改善了伤口愈合（p < 0.05）。PEP被三种不同的子宫内膜细胞类型摄取。PEP处理增加了细胞增殖和伤口愈合能力。
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