Taub Amy Forman
Institute Advanced Dermatology, A Forefront Dermatology Practice, Lincolnshire, IL, United States.
Department of Dermatology, Institute Northwestern University Medical School, Chicago, IL, United States.
Front Med (Lausanne). 2024 Oct 15;11:1443963. doi: 10.3389/fmed.2024.1443963. eCollection 2024.
Regenerative medicine and its offshoot, regenerative aesthetics, have been hot topics over the past 15 years. Studies with heterochronic parabiosis and others pointed to a circulating factor that could rejuvenate aging tissues. Stem cells are known to have regenerative powers, but they are difficult to extract, grow in culture or maintain. Exosomes (EVs), extracellular vesicles from 30 to 150 nm, have been discovered to be a primary form of communication between tissues. Using stem cell supernatants to generate desirable EVs has become a heralded treatment for aesthetic treatments. Preclinical studies with EVs show many benefits including improving the function of fibroblasts and healing wounds more rapidly. Clinical studies with EVs in aesthetics are very few. Thus, the excitement generated by EVs should be tempered with realism about the lack of available treatment products as well as the lack of scientific proof.
再生医学及其分支——再生美学，在过去15年里一直是热门话题。异时联体共生等研究指出，存在一种可使衰老组织恢复活力的循环因子。干细胞具有再生能力，但难以提取、在培养中生长或维持。外泌体（细胞外囊泡）大小为30至150纳米，已被发现是组织间通信的主要形式。利用干细胞上清液生成理想的外泌体已成为一种备受推崇的美容治疗方法。外泌体的临床前研究显示出许多益处，包括改善成纤维细胞功能和加速伤口愈合。外泌体在美容领域的临床研究非常少。因此，鉴于缺乏可用的治疗产品以及科学证据，对外泌体所产生的兴奋之情应保持理性。
