Department of Medicinal Chemistry Ernest Mario School of Pharmacy, Rutgers, the State University of New Jersey 163 Frelinghuysen Road, Piscataway New Jersey 08901, United States.
Org Lett. 2022 Oct 14;24(40):7394-7399. doi: 10.1021/acs.orglett.2c02932. Epub 2022 Oct 4.
Functionalized pyridine and quinoline rings are important components of numerous bioactive molecules and natural products; however, diversification of these rings often requires heterocycle ring synthesis or demanding reaction conditions. We report a method for desulfinative alkylation of pyridine and quinoline -methoxide salts that operates under both photocatalytic and electrostatic electron donor-acceptor-mediated pathways. Unlike most EDA-mediated processes, this reaction operates in the absence of light and with the desulfination of the donor compound.
功能化的吡啶环和喹啉环是许多生物活性分子和天然产物的重要组成部分；然而，这些环的多样化通常需要杂环合成或苛刻的反应条件。我们报告了一种在光催化和静电电子给体-受体介导途径下进行吡啶和喹啉甲氧基盐的去磺化烷基化的方法。与大多数 EDA 介导的过程不同，该反应在没有光的情况下并且伴随着供体化合物的脱硫进行。
